毒理学数据:
1. 致肿瘤:大鼠肌肉TDLo:117mg/kg;大鼠肾脏TDLo:58580ug/kg
CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
QR9710000
-
CHEMICAL NAME :
-
Nickel sulfide
-
CAS REGISTRY NUMBER :
-
12035-51-7
-
LAST UPDATED :
-
199712
-
DATA ITEMS CITED :
-
26
-
MOLECULAR FORMULA :
-
Ni-S2
-
MOLECULAR WEIGHT :
-
122.83
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intramuscular
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
117 mg/kg
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Musculoskeletal - tumors Tumorigenic - tumors at site of application
-
REFERENCE :
-
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.27- 1979- Volume(issue)/page/year: 53,127,1984
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intrarenal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
58580 ug/kg
-
TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Tumorigenic - tumors at site of application
-
REFERENCE :
-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1511,1984 *** REVIEWS *** ACGIH TLV-TWA 1 mg(Ni)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 49,257,1990 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.1 mg(Ni)/m3 JAN 1993 OEL-AUSTRALIA:TWA 1 mg(Ni)/m3 JAN 1993 OEL-BELGIUM:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993 OEL-DENMARK:TWA 0.05 mg(Ni)/m3;Carcinogen JAN 1993 OEL-DENMARK:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993 OEL-FINLAND:TWA 0.1 mg(Ni)/m3;Skin;Carcinogen (insoluble compounds) JAN 1993 OEL-FRANCE:TWA 1 mg(Ni)/m3 JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-HUNGARY:STEL 0.005 mg(Ni)/m3;Carcinogen (insoluble compounds) JAN 1993 OEL-JAPAN:TWA 1 mg(Ni)/m3;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 mg(Ni)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993 OEL-THE PHILIPPINES:TWA 1 mg(Ni)/m3 JAN 1993 OEL-RUSSIA:STEL 0.05 mg(Ni)/m3 JAN 1993 OEL-SWEDEN:TWA 0.5 mg(Ni)/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993 OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3;Carcinogen JAN 1993 OEL-THAILAND:TWA 1 mg(Ni)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993 OEL-UNITED KINGDOM:TWA 1 mg(Ni)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
|