872728-85-3

• 常用中文名：达比加群酯中间体
• 常用英文名：N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridin
• CAS号：872728-85-3
• 分子式：C₃₈H₄₇N₇O₉S
• 分子量：777.886
• 相关类别： 生物化工 氨基酸及其衍生物 丙氨酸类衍生物
• 发布时间：2018-02-22 08:00:00
• 更新时间：2026-07-15 00:32:27

名称

• 中文名: N-[[2-[[[4-(氨基亚氨基甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-beta-丙氨酸乙酯 4-甲基苯磺酸盐
• 英文名: N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridin
• 中文别名: N-[[2-[[[(4-(氨基亚胺甲基)苯基]胺基]甲基]-1甲基-1H-5-苯并咪唑]羰基]-N-2-吡啶基-丙氨酸乙酯 对甲苯磺酸盐; N-[[2-[[[4-(氨基亚氨基甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-BET-1-丙氨酸乙酯 4-甲基苯磺酸盐,抗血栓药 达比加群中间体; 达比加群酯杂质18; 达比加群酯中间体(DBJQ-E); N-[[2-[[[4-(氨基亚氨基甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-BET-1-丙氨酸乙酯 4-甲基苯磺酸盐,抗血栓药 达比加群中间体 G; 达比加群杂质51; 达比加群中间体DB-7; 甲磺酸达比加群酯N-2; 达比加群酯杂质; 达比加群酯相关化合物B(对甲苯磺酸盐); N-[[2-[[[4-(氨基亚氨基甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-BETA-丙氨酸乙酯 4-甲基苯磺酸盐; 3-(2-(((4-氨基甲酰苯基)氨基)甲基)-1-甲基-N-(吡啶-2-基)-1H-苯并[D]咪唑-5-甲酰氨基)丙酸乙酯4-甲基苯磺酸酯; 达比加群酯杂质16 对甲苯磺酸盐; N-[[2-[[[4-(氨基亚氨基甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-BET-1-丙氨酸乙酯4-甲基苯磺酸盐; 达比加群酯中间体N-1; 3-[[[2-[[(4-脒基苯基)氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羧基])吡啶-2-基)氨基]丙酸乙酯对甲基苯磺酸盐; 甲磺酸达比加群酯中间体; 达比加群杂质59; N-[[2-[[[4-(氨基亚氨基甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-BETA-丙氨酸乙酯 4-甲基苯磺酸盐,抗血栓药 达比加群中间体; 达比加群酯杂质B(对甲苯磺酸盐)
• 英文别名: Dabigatran ethyl ester tosylate; Dabigatran Impurity 16 p-Toluenesulfonate; Ethyl 3-(((2R,3S,4R)-1-(2-(((4-cbamimidoylphenyl)amino)methyl)-1-methyl-1H-benzo[d]imidazol; N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]bonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfona; Dabigatran etexilate/N-2; Ethyl 3-{[(2R,3S,4R)-1-(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)-2,3,4,5-tetrahydroxypentyl](2-pyridinyl)amino}propanoate 4-methylbenzenesulfonate (1:1) (non-preferred name); N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]bonyl]-N-2-pyridin; Alanine,N- 2- 4-(aMinoiMinoMethyl)phenyl amino Methyl -1-Methyl-1H-benziMidazol-5-yl carbonyl -N-2-pyridinyl-,ethyl ester,4-Methylbenzenesulfonate(1 1); N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]bonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate; Dabigatran impurity 26/Dabigatran ethyl ester tosylate/1-methyl-2-[N-[4-amidinophenyl]aminomethyl]benzimidazole-5-cboxylic acid N-(2-pyridyl)-N-(2-ethoxycbonylethyl)amide tosylate; β-Alanine, N-[[2-[[[4-(aMinoiMinoMethyl)phenyl]amino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, 4-Methylbenzenesulfonat; D-Arabinitol, 1-[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]-1-deoxy-1-[(3-ethoxy-3-oxopropyl)-2-pyridinylamino]-, (1ξ)-, 4-methylbenzenesulfonate (1:1); InterMediates of Dabigatran; Dabigatran etexilate-18; 1-methyl-2-[N-[4-amidinophenyl]aminomethyl]benzimidazol-5-yl-carboxylicacid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide para-toluene sulfonate; Dabigatran etexilate impurity176; Ethyl 3-(2-(((4-cbaMiMidoylphenyl)amino)Methyl)-1-Methyl-N-(pyridin-2-yl)-1H-benzo[d]iMidazole-5-cboxaMido)propanoate 4-Methylbenzenesulfonate; Dabigatran Impurity 59; DB-7; N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1; Dabigatran ester impurity 18; N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]bonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate //BP; N-[[2-[[[4-(AMinoiMinoMethyl)phenyl]amino]Methyl]-1- Methyl-1H-benziMidazol-5-yl] carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-Methylbenzenesulfonate; 1-methyl-2-[N-[4-amidinophenyl]aminomethyl]benzimidazole-5-carboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide tosylate; N-[[2-[[[4-(AMinoiMinoMethyl)phenyl]amino]Methyl]-1- Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester tosylate

物化性质

• 分子式: C₃₈H₄₇N₇O₉S
• 分子量: 777.886
• 精确质量: 777.315613
• PSA: 265.82000
• LogP: 4.63590

合成路线

872728-84-2 104-15-4 ~92% 872728-85-3

文献：BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG Patent: WO2007/71742 A1, 2007 ; Location in patent: Page/Page column 25 ;

上下游产品

上游产品  2
872728-84-2 104-15-4
下游产品  1
872728-81-9