872728-81-9

• 常用中文名：甲磺酸达比加群酯
• 常用英文名：Dabigatran etexilate mesylate
• CAS号：872728-81-9
• 分子式：C₃₅H₄₅N₇O₈S
• 分子量：723.839
• 相关类别： 原料药 血液系统用药 抗凝血药及抗血小板药
• 发布时间：2018-08-31 19:29:29
• 更新时间：2024-01-02 18:15:03
• Dabigatran etexilate mesylate (BIBR 1048MS)是口服活性的dabigatran前药。Dabigatran是可逆的直接凝血酶抑制剂(DTI),Ki为4.5 nM。

名称

• 中文名: 甲磺酸达比加群酯
• 英文名: dabigatran etexilate methanesulfonate
• 中文别名: 达比加群酯; 达比加群酯甲磺酸盐
• 英文别名: N-[[2-[[[4-[[[(HEXYLOXY)CARBONYL]AMINO]IMINOMETHYL]PHENYL]AMINO]METHYL]-1-METHYL-1H-BENZIMIDAZOL-5-Y; β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, methanesulfonate (1:1); Pradaxa; BIBR-1048 (DABIGATRAN)METHANESULFONATE; Ethyl N-[(2-{[(4-{N-[(hexyloxy)carbonyl]carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-2-pyridinyl-β-alaninate methanesulfonate (1:1); Dabigatran etexilate mesilate impurity; Dabigatran etexilate (mesylate); Dabigatran etexilate; PRODUCTS Dabigatran etexilate mesylate; Dabigatran Etexilate Mesylate; dabigatran etexilate methanesulfonate; Pradaxa mesylate

物化性质

• 分子式: C₃₅H₄₅N₇O₈S
• 分子量: 723.839
• 精确质量: 723.305054
• PSA: 216.78000
• LogP: 6.96070
• 储存条件: 2-8°C

生物活性

• 描述: Dabigatran etexilate mesylate (BIBR 1048MS)是口服活性的dabigatran前药。Dabigatran是可逆的直接凝血酶抑制剂(DTI),Ki为4.5 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 凝血酶
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Wienen W, Stassen JM, Priepke H, In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally activeprodrug, dabigatran etexilate. Thromb Haemost. 2007 Jul;98(1):155-62.

  [2]. Kansal AR, Sorensen SV, Gani R, Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients withatrial fibrillation. Heart. 2012 Apr;98(7):573-8.

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