143383-65-7

• 常用中文名：沛马沙星
• 常用英文名：permafloxacin
• CAS号：143383-65-7
• 分子式：C₂₁H₂₆FN₃O₄
• 分子量：403.44700
• 相关类别： 原料药 人工合成抗感染类药 喹诺酮类药
• 发布时间：2018-09-19 07:46:53
• 更新时间：2025-08-25 16:31:36

名称

• 中文名: 沛马沙星
• 英文名: 1-cyclopropyl-6-fluoro-8-methoxy-7-[(3R)-3-[(1S)-1-(methylamino)ethyl]pyrrolidin-1-yl]-4-oxoquinoline-3-carboxylic acid
• 英文别名: 1-cyclopropyl-6-fluoro-8-methoxy-7-[3-(1-methylamino-ethyl)-pyrrolidin-1-yl]-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; Premafloxacin (USAN/INN); Premafloxacin; JB-1; UNII-UOM2HMO524

物化性质

• 密度: 1.354g/cm3
• 沸点: 601.3ºC at 760mmHg
• 分子式: C₂₁H₂₆FN₃O₄
• 分子量: 403.44700
• 闪点: 317.4ºC
• 精确质量: 403.19100
• PSA: 83.80000
• LogP: 3.07240
• 蒸汽压: 2.63E-15mmHg at 25°C
• 折射率: 1.615

合成路线

143409-01-2 ~% 143383-65-7

文献：Murphy, Sean T.; Case, Heather L.; Ellsworth, Edmund; Hagen, Susan; Huband, Michael; Joannides, Themis; Limberakis, Chris; Marotti, Keith R.; Ottolini, Amy M.; Rauckhorst, Mark; Starr, Jeremy; Stier, Michael; Taylor, Clarke; Zhu, Tong; Blaser, Adrian; Denny, William A.; Lu, Guo-Liang; Smaill, Jeff B.; Rivault, Freddy Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2150 - 2155

143409-16-9 ~% 143383-65-7

文献：Murphy, Sean T.; Case, Heather L.; Ellsworth, Edmund; Hagen, Susan; Huband, Michael; Joannides, Themis; Limberakis, Chris; Marotti, Keith R.; Ottolini, Amy M.; Rauckhorst, Mark; Starr, Jeremy; Stier, Michael; Taylor, Clarke; Zhu, Tong; Blaser, Adrian; Denny, William A.; Lu, Guo-Liang; Smaill, Jeff B.; Rivault, Freddy Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2150 - 2155

143408-75-7 ~% 143383-65-7

文献：Murphy, Sean T.; Case, Heather L.; Ellsworth, Edmund; Hagen, Susan; Huband, Michael; Joannides, Themis; Limberakis, Chris; Marotti, Keith R.; Ottolini, Amy M.; Rauckhorst, Mark; Starr, Jeremy; Stier, Michael; Taylor, Clarke; Zhu, Tong; Blaser, Adrian; Denny, William A.; Lu, Guo-Liang; Smaill, Jeff B.; Rivault, Freddy Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2150 - 2155

847233-56-1 ~% 143383-65-7

文献：Murphy, Sean T.; Case, Heather L.; Ellsworth, Edmund; Hagen, Susan; Huband, Michael; Joannides, Themis; Limberakis, Chris; Marotti, Keith R.; Ottolini, Amy M.; Rauckhorst, Mark; Starr, Jeremy; Stier, Michael; Taylor, Clarke; Zhu, Tong; Blaser, Adrian; Denny, William A.; Lu, Guo-Liang; Smaill, Jeff B.; Rivault, Freddy Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2150 - 2155

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