28987-79-3

• 常用中文名：间甲苯基溴化镁
• 常用英文名：m-tolylmagnesium bromide
• CAS号：28987-79-3
• 分子式：C₇H₇BrMg
• 分子量：195.33900
• 相关类别： 化学试剂 格氏试剂
• 发布时间：2018-08-14 15:50:10
• 更新时间：2024-01-03 18:50:59

名称

• 中文名: 间甲苯基溴化锰
• 英文名: m-tolylmagnesium bromide
• 中文别名: 间甲苯基溴化镁溶液; 3-甲基苯基溴化镁; 间甲苯基溴化镁
• 英文别名: 3-tolylmagnesium bromide; m-Tolylmagnesium Bromide; m-methylphenyl magnesium bromide; 3-methyl-phenylmagnesium bromide; Tolylmagnesiumbromide

物化性质

• 分子式: C₇H₇BrMg
• 分子量: 195.33900
• 闪点: -17ºC (THF)
• 精确质量: 193.95800
• LogP: 2.64080
• 外观性状: 液体
• 储存条件:

  保持贮藏器密封、储存在阴凉、干燥的地方，确保工作间有良好的通风或排气装置

• 稳定性:

  如果遵照规格使用和储存则不会分解，未有已知危险反应

• 更多:

  1. 性状：未确定

  2. 密度（g/mL,25℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC, KPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：-17

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（Pa,70ºC）：未确定

  12. 饱和蒸气压（KPa,20ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

MSDS

m-Tolylmagnesium Bromide (19% in Tetrahydrofuran, Revision number: 5 ca. 1mol/L) SAFETY DATA SHEET Section1. IDENTIFICATION Product name:m-Tolylmagnesium Bromide (19% in Tetrahydrofuran, ca. 1mol/L) Revision number:5 Section2. HAZARDS IDENTIFICATION GHS classification PHYSICAL HAZARDS Category 2 Flammable liquids HEALTH HAZARDS Category 4 Acute toxicity (Oral) Skin corrosion/irritationCategory 1B Serious eye damage/eye irritationCategory 1 Specific target organ toxicityNervous system - Single exposure [Category 2] Specific target organ toxicityRespiratory tract irritation - Single exposure [Category 3] Specific target organ toxicityLiver, Nervous system, Kidney - Repeated exposure [Category 1] ENVIRONMENTAL HAZARDSNot classified GHS label elements, including precautionary statements Pictograms or hazard symbols Signal wordDanger Hazard statementsHighly flammable liquid and vapour Harmful if swallowed Causes severe skin burns and eye damage May cause damage to organs : Nervous system Causes damage to organs through prolonged or repeated exposure : Liver Nervous system Kidney May cause respiratory irritation Precautionary statements: m-Tolylmagnesium Bromide (19% in Tetrahydrofuran, ca. 1mol/L) Section2. HAZARDS IDENTIFICATION [Prevention]Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Use explosion-proof electrical/ventilating/lighting equipment. Take precautionary measures against ignition by the static discharge and the spark. Do not breathe dust/fume/gas/mist/vapours/spray. Use only outdoors or in a well-ventilated area. Do not eat, drink or smoke when using this product. Wash hands thoroughly after handling. Wear protective gloves/eye protection/face protection. [Response]IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash contaminated clothing before reuse. Immediately call a POISON CENTER or doctor/physician. Store in a well-ventilated place. Keep container tightly closed. [Storage] Store locked up. Dispose of contents/container through a waste management company authorized by [Disposal] the local government. Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substance/mixture:Mixture Components:m-Tolylmagnesium Bromide (19% in Tetrahydrofuran, ca. 1mol/L) Percent:.... CAS Number:28987-79-3 Chemical Formula:C7H7BrMg Section4. FIRST AID MEASURES Inhalation:Remove victim to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Skin contact:Remove/Take off immediately all contaminated clothing. Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/physician. Eye contact:Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Immediately call a POISON CENTER or doctor/physician. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT Ingestion: induce vomiting. A rescuer should wear personal protective equipment, such as rubber gloves and air- Protection of first-aiders: tight goggles. Section5. FIRE-FIGHTING MEASURES Suitable extinguishingDry chemical, dry sand. media: Unsuitable extinguishing Water media: Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to generate poisonous fume. from the chemical: Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In case of fire in the surroundings: Keep containers cool by spraying with water but NO direct contact with water. Eliminate all ignition sources if safe to do so. m-Tolylmagnesium Bromide (19% in Tetrahydrofuran, ca. 1mol/L) Section5. FIRE-FIGHTING MEASURES Special protectiveWhen extinguishing fire, be sure to wear personal protective equipment. equipment for firefighters: Section6. ACCIDENTAL RELEASE MEASURES Personal precautions,Use extra personal protective equipment (self-contained breathing apparatus). Keep protective equipment and people away from and upwind of spill/leak. Ensure adequate ventilation. Entry to non- emergency procedures: involved personnel should be controlled around the leakage area by roping off, etc. Environmental precautions: Prevent product from entering drains. Methods and materials for Absorb spilled material in dry sand or inert absorbent before recovering it into an containment and cleaning airtight container. In case of large amount of spillage, contain a spill by bunding. up: Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations. Prevention of secondary Do not allow contact with water. Remove all sources of ignition. Fire-extinguishing hazards:devices should be prepared in case of a fire. Use spark-proof tools and explosion- proof equipment. Section7. HANDLING AND STORAGE Precautions for safe handling Handling is performed in a well ventilated place. Wear suitable protective equipment. Technical measures: Prevent generation of vapour or mist. Keep away from heat/sparks/open flame/hot surfaces. -No smoking. Take measures to prevent the build up of electrostatic charge. Use explosion-proof equipment. Wash hands and face thoroughly after handling. Use a closed system if possible. Use a ventilation, local exhaust if vapour or aerosol will be generated. Advice on safe handling:Avoid contact with skin, eyes and clothing. Use well-dried equipment. Handle under inert gas. Don't leave used equipment or rag. This product may ignite if it is left stuck on combustibles such as paper, rags, etc. Conditions for safe storage, including any incompatibilities Storage conditions:Keep container tightly closed. Store in a cool, dark and well-ventilated place. Store under inert gas. Protect from moisture. Store locked up. Store away from incompatible materials such as oxidizing agents. Moisture-sensitive Packaging material:Comply with laws. Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION Engineering controls:Install a closed system or local exhaust. Also install safety shower and eye bath. Exposure limits:(THF) ACGIH TLV(TWA):50 ppm (skin) ACGIH TLV(STEL):100 ppm (skin) OSHA PEL(TWA):200 ppm Personal protective equipment Respiratory protection: Half or full facepiece respirator, self-contained breathing apparatus(SCBA), supplied air respirator, etc. Use respirators approved under appropriate government standards and follow local and national regulations. Hand protection:Impervious gloves. Eye protection:Safety goggles. A face-shield, if the situation requires. Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires. Section9. PHYSICAL AND CHEMICAL PROPERTIES Physical state (20°C):Liquid m-Tolylmagnesium Bromide (19% in Tetrahydrofuran, ca. 1mol/L) Section9. PHYSICAL AND CHEMICAL PROPERTIES Odour:No data available pH: No data available Melting point/freezing point:No data available (THF) -108°C Boiling point/range:No data available (THF) 65°C Flash point:No data available (THF) -15°C Flammability or explosive limits: Lower:No data available Upper:No data available No data available Relative density: Solubility(ies): [Water]No data available [Other solvents]No data available Log Pow:(THF) 0.46 Section10. STABILITY AND REACTIVITY Chemical stability:Stable under proper conditions. Possibility of hazardous No special reactivity has been reported. reactions: Spark, Open flame, Static discharge, Moisture Conditions to avoid: Incompatible materials: Oxidizing agents, Water Hazardous decomposition Carbon monoxide, Carbon dioxide, Hydrogen chloride, Hydrogen bromide products: Section11. TOXICOLOGICAL INFORMATION Acute Toxicity:No data available (THF) orl-rat LD50:1650 mg/kg ihl-rat LC50:21000 ppm/3H ipr-rat LD50:2900 mg/kg Skin corrosion/irritation: No data available Serious eyeNo data available damage/irritation: Germ cell mutagenicity: No data available (THF) mmo-esc 1 umol/L (-S9) Carcinogenicity: IARC =No data available No data available NTP = (THF) ihl-rat TCLo:18900 mg/kg/105W-I Reproductive toxicity:No data available Section12. ECOLOGICAL INFORMATION Ecotoxicity: Fish:No data available Crustacea:No data available Algae:No data available Persistence / degradability: No data available BioaccumulativeNo data available potential(BCF): Mobility in soil Log Pow:No data available m-Tolylmagnesium Bromide (19% in Tetrahydrofuran, ca. 1mol/L) Section12. ECOLOGICAL INFORMATION Soil adsorption (Koc): No data available Henry's LawNo data available constant(PaM3/mol): Section13. DISPOSAL CONSIDERATIONS Recycle to process, if possible. Consult your local regional authorities and an expert of disposal. Take precautions against ignition. Observe all federal, state and local regulations when disposing of the substance Section14. TRANSPORT INFORMATION Hazards Class:3: Flammable liquid. Subsidiary risk:8: Corrosive. UN-No:2924 Proper shipping name:Flammable liquid, corrosive, n.o.s. Packing group:II Section15. REGULATORY INFORMATION Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002 and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were prescribed. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 若无政府许可，勿将材料排入周围环境。

安全

• 风险声明 (欧洲): 11-14/15-19-34
• 安全声明 (欧洲): 16-26-43
• 危险品运输编码: UN 2924
• 包装等级: II
• 海关编码: 2931900090

合成路线

591-17-3 ~% 28987-79-3

文献：Xue, Fei; Zhao, Jin; Hor, T. S. Andy Chemical Communications, 2013 , vol. 49, # 86 p. 10121 - 10123

591-17-3 7439-95-4 ~% 28987-79-3

文献：VITAE PHARMACEUTICALS, INC. Patent: WO2008/156817 A2, 2008 ; Location in patent: Page/Page column 145-146 ; WO 2008/156817 A2

海关

海关编码	2931900090
中文概述	2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%