209799-67-7

209799-67-7结构式

常用中文名：7-[(2S,3S,4R,5R)-3,4-二羟基-5-(羟甲基)-2-吡咯烷基]-3,5-二氢-4H-吡咯并[3,2-D]嘧啶-4-酮
常用英文名：Forodesine
CAS号：209799-67-7
分子式：C₁₁H₁₄N₄O₄
分子量：266.25300
相关类别：信号通路细胞周期/DNA损伤核苷抗代谢药/类似物
发布时间：2018-10-14 20:30:36
更新时间：2026-07-06 18:11:38
Forodesine(BCX-1777 freebase; Immucillin-H)是口服活性嘌呤核苷磷酸化酶(PNP)抑制剂,能诱导细胞凋亡,特别是在T淋巴细胞中。

中文名	7-[(2S,3S,4R,5R)-3,4-二羟基-5-(羟甲基)-2-吡咯烷基]-3,5-二氢-4H-吡咯并[3,2-D]嘧啶-4-酮
英文名	immucillin H
中文别名	Forodesine试剂呋咯地辛化合物:Forodesine (BCX-1777 freebase) 化合物：Forodesine (BCX-1777 freebase) 7-((2S,3S,4R,5R)-3,4-二羟基-5-(羟甲基)吡咯烷-2-基)-3,5-二氢-4H-吡咯并[3,2-D]嘧啶-4-酮
英文别名	(1S)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride 4H-Pyrrolo[3,2-d]pyriMidin-4-one,7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-2-pyrrolidinyl]-3,5-dihydro Isopamphos FORODESINE FODOSINE Immucillin-H 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro BCX-1777 freebase Fodosine 7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol, iMMucillin H 7-((2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

描述	Forodesine(BCX-1777 freebase; Immucillin-H)是口服活性嘌呤核苷磷酸化酶(PNP)抑制剂,能诱导细胞凋亡,特别是在T淋巴细胞中。
相关类别	信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物研究领域 >> 癌症
参考文献	[1]. Homminga I, et al. In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia. Blood. 2011 Aug 25;118(8):2184-90. [2]. Ogura M, et al. Phase I study of BCX1777 (forodesine) in patients with relapsed or refractory peripheral T/natural killer-cell malignancies. Cancer Sci. 2012 Jul;103(7):1290-5. [3]. Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895. [4]. Yamauchi T, et al. A nelarabine-resistant T-lymphoblastic leukemia CCRF-CEM variant cell line is cross-resistant to the purine nucleoside phosphorylase inhibitor forodesine. Anticancer Res. 2014 Sep;34(9):4885-92.