209860-87-7

• 常用中文名：他氟前列素
• 常用英文名：Tafluprost
• CAS号：209860-87-7
• 分子式：C₂₅H₃₄F₂O₅
• 分子量：452.531
• 相关类别： 原料药 激素及调节内分泌功能类药 前列腺素类药
• 发布时间：2018-06-01 08:00:00
• 更新时间：2026-07-03 12:11:38
• Tafluprost(AFP-168)是抗青光眼前列腺素(PG)类似物。

名称

• 中文名: 他氟前列素
• 英文名: tafluprost
• 中文别名: Tafluprost :他氟前列素; 他氟前列腺素/Tafluprost; 他氟前列腺素杂质; 他氟前列素TAFLUPROST; 他氟前列素 D; (Z)-异丙基 7-((1R,2R,3R,5S)-2-((E)-3,3-二氟-4-苯氧基丁-1-烯-1-基)-3,5-二羟基环戊基)庚-5-烯酸酯; 他氟前列素,10 MM DMSO 溶液; 他氟前列酮; 他佛前列素; MK2452|||AFP-168|||他氟前列素; (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-二氟-4-苯氧基-1-丁烯-1-基]-3,5-二羟基环戊基]-5-庚烯酸异丙酯; (5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-二氟-4-苯氧基-1-丁烯-1-基]-3,5-二羟基环戊基]-5-庚烯酸异丙酯; 甲醇中他氟前列素溶液标准物质; 他氟前列素 :他氟前列酮
• 英文别名: TafluprostQ: What is Tafluprost Q: What is the CAS Number of Tafluprost Q: What is the storage condition of Tafluprost Q: What e the applications of Tafluprost; (Z)Isopropyl 7-((1R,2R,3R,5S)-2-((E)-3,3-difluoro-4-phenoxy-but-1-en-1-yl)-3,5-dihydroxy-cyclopentyl)ht-5-enoat; MK2452|||AFP-168; propan-2-yl (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-phenoxybut-1-enyl]-3,5-dihydroxycyclopentyl]ht-5-enoate; Tafluprost, 10 mM in DMSO; He has fluprostaglandin; UNII-1O6WQ6T7G3; Tapros; TAFLUPROST; TafL; 209-7 Tafluprost; propan-2-yl (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-phenoxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate; Isopropyl (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-htenoate; AFP-168; (Z)-Isopropyl 7-((1R,2R,3R,5S)-2-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)ht-5-enoate; propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl]ht-5-enoate; Zioptan; MK2452; MK-2452; 5-Htenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-, 1-methylethyl ester, (5Z); aflupros; Tafluprost //BP; Tafluprosttrade; Tafluprost5-Htenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-,1-methylethyl ester, (5Z); Saflutan; (5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-htenoic acid 1-methylethyl ester; 15,15-DIFLUORO-9ALPHA,11ALPHA-DIHYDROXY-16-PHENOXY-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER; Isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-((1E)-3,3-difluoro-4-phenoxybut-1-enyl)-3,5-dihydroxycyclopentyl}hept-5-enoate; Taflotan; TAFLUPROST DRUG SUBSTANCE; isopropyl (z)-7-((1r,2r,3r,5s)-2-((e)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)ht-5-enoate; Isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-5-heptenoate; uprost

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 552.9±50.0 °C at 760 mmHg
• 分子式: C₂₅H₃₄F₂O₅
• 分子量: 452.531
• 闪点: 288.2±30.1 °C
• 精确质量: 452.237427
• PSA: 75.99000
• LogP: 4.23
• 外观性状: 粉末
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.549
• 储存条件: -20℃

生物活性

• 描述: Tafluprost(AFP-168)是抗青光眼前列腺素(PG)类似物。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
• 参考文献:

  [1]. Kuwayama, Y. and A. Nomura, Prospective observational post-marketing study of tafluprost for glaucoma and ocular hypertension: short-term efficacy and safety. Adv Ther, 2014. 31(4): p. 461-71.

  [2]. Kumagami, T., et al., Comparison of corneal safety and intraocular pressure-lowering effect of tafluprost ophthalmic solution with other prostaglandin ophthalmic solutions. J Ocul Pharmacol Ther, 2014. 30(4): p. 340-5.

  [3]. Inoue, K., A. Tanaka, and G. Tomita, Effects of tafluprost treatment for 3 years in patients with normal-tension glaucoma. Clin Ophthalmol, 2013. 7: p. 1411-6.