254881-77-1

• 常用中文名：(2R,4S)-1-叔丁基 2-甲基 4-氨基吡咯烷-1,2-二甲酸酯
• 常用英文名：(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate
• CAS号：254881-77-1
• 分子式：C₁₁H₂₀N₂O₄
• 分子量：244.288
• 发布时间：2018-12-25 15:05:09
• 更新时间：2026-07-03 19:18:39

名称

• 中文名: (2R,4S)-1-叔丁基 2-甲基 4-氨基吡咯烷-1,2-二甲酸酯
• 英文名: Methyl (2R,4S)-4-aminopyrrolidine-2-carboxylate, N1-BOC protected
• 中文别名: 1-叔-丁基 2-甲基 (2R,4S)-4-氨基吡咯烷-1,2-二甲酸基酯; (2R,4S)-N1-BOC-4-氨基吡咯烷-2-甲酸甲酯; N-Boc-反式-4-氨基-D-脯氨酸甲酯; (2R,4S)-1-BOC-4-氨基-2-吡咯烷甲酸甲酯
• 英文别名: 1-(1,1-Dimethylethyl) 2-methyl (2R,4S)-4-amino-1,2-pyrrolidinedicboxylate; (4S)-4-Amino-1-(tert-butoxycarbonyl)-2-methyl-D-proline; Methyl (2R,4S)-4-aminopyrrolidine-2-cboxylate, N1-BOC protected, trans-4-Amino-D-proline methyl ester, N1-BOC protected, (2R,4S)-4-amino-1-(tert-butoxycbonyl)-2-(methoxycbonyl)pyrrolidine; (2r,4s)-1-tert-butyl 2-methyl 4-aminopyrrolidine-1,2-dicboxylate; N-a-butoxycarbonyl-trans-4-amino-L-prolinemethyl ester; (2R,4S)-4-AMINO-1-BOC-PYRROLIDINE-2-CBOXYLIC ACID METHYL ESTER-HCl; (4S)-4-Amino-2-methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline; 2-Methyl 1-(2-methyl-2-propanyl) (2R,4S)-4-amino-1,2-pyrrolidinedicarboxylate; (4S)-4-Amino-1-Boc-D-proline methyl ester; (2R,4S)-N-Boc-4-amino-D-proline methyl ester; (2R,4S)-4-Amino-1,2-pyrrolidinedicboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester; Methyl (2R,4S)-4-Amino-1-Boc-2-pyrrolidinedicboxylate; 1-(tert-Butyl) 2-methyl (2R,4S)-4-amino-1,2-pyrrolidinedicboxylate; 1,2-Pyrrolidinedicboxylic acid, 4-amino-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4S); Methyl (2R,4S)-1-(tert-butoxycbonyl)-4-aMinopyrrolidine-2-cboxylate; (2R,4S)-4-Amino-1,2-pyrrolidinedicboxylic acid 1-(tert-butyl) 2-methyl ester; trans-4-amino-N-tert-butoxycarbonyl-D-proline methyl ester; Methyl (2R,4S)-4-aminopyrrolidine-2-cboxylate, N1-BOC protected; Methyl (2R,4S)-4-Amino-1-Boc-2-pyrrolidinecboxylate; 1-tert-Butyl 2-methyl (2R,4S)-4-aminopyrrolidine-1,2-dicboxylate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 370.2±42.0 °C at 760 mmHg
• 分子式: C₁₁H₂₀N₂O₄
• 分子量: 244.288
• 闪点: 177.7±27.9 °C
• 精确质量: 244.142303
• PSA: 81.86000
• LogP: 0.18
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.507
• 储存条件: 室温

合成路线

24424-99-5 ~% 254881-77-1

文献：Journal of Medicinal Chemistry, , vol. 43, # 26 p. 4948 - 4963

148017-26-9 ~% 254881-77-1

文献：Journal of Medicinal Chemistry, , vol. 43, # 26 p. 4948 - 4963

135042-09-0 ~% 254881-77-1

文献：Tetrahedron, , vol. 52, # 47 p. 15017 - 15030

185304-04-5 ~61% 254881-77-1

文献：Natchus; Bookland; De; Almstead; Pikul; Janusz; Heitmeyer; Hookfin; Hsieh; Dowty; Dietsch; Patel; Garver; Gu; Pokross; Mieling; Baker; Foltz; Peng; Bornes; Strojnowski; Taiwo Journal of Medicinal Chemistry, 2000 , vol. 43, # 26 p. 4948 - 4963

114676-69-6 ~% 254881-77-1

文献：Journal of Medicinal Chemistry, , vol. 43, # 26 p. 4948 - 4963

114676-59-4 ~% 254881-77-1

文献：Journal of Medicinal Chemistry, , vol. 43, # 26 p. 4948 - 4963

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185304-04-5 24424-99-5 114676-69-6 114676-59-4
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