FT011

• 常用名: FT011
• 英文名: FT011
• CAS号: 1001288-58-9
• 分子量: 351.353
• 密度: 1.3±0.1 g/cm3
• 沸点: 618.9±55.0 °C at 760 mmHg
• 分子式: C₂₀H₁₇NO₅
• 熔点: N/A
• 闪点: 328.1±31.5 °C

FT011用途

FT011是一个新的抗纤维化和抗炎症的化合物，通过减少糖原蛋白mRNA翻译阻止糖原累积。

FT011名称

• 中文名: FT011
• 英文名: FT011

FT011生物活性

• 描述: FT011是一个新的抗纤维化和抗炎症的化合物,通过减少糖原蛋白mRNA翻译阻止糖原累积。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Lau X Attenuation of Armanni-Ebstein lesions in a rat model of diabetes by a new anti-fibrotic, anti-inflammatory agent, FT011. Diabetologia. 2013 Mar;56(3):675-9.

  [2]. Deliyanti D et al. FT011, a Novel Cardiorenal Protective Drug, Reduces Inflammation, Gliosis and Vascular Injury in Rats with Diabetic Retinopathy. PLoS One. 2015 Jul 29;10(7):e0134392.

  [3]. Gilbert RE et al. A purpose-synthesised anti-fibrotic agent attenuates experimental kidney diseases in the rat. PLoS One. 2012;7(10)

FT011物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 618.9±55.0 °C at 760 mmHg
• 分子式: C₂₀H₁₇NO₅
• 分子量: 351.353
• 闪点: 328.1±31.5 °C
• 精确质量: 351.110687
• LogP: 4.39
• InChIKey: UIWZIDIJCUEOMT-PKNBQFBNSA-N
• SMILES: C#CCOc1ccc(C=CC(=O)Nc2ccccc2C(=O)O)cc1OC
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.656
• 储存条件: 2-8℃

FT011靶点实验

查看更多实验

实验名称：Antifibrotic activity in rat 1097 cells assessed as inhibition of TGF-beta-stimulated... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1115708

实验名称：Antifibrotic activity in rat 1097 cells assessed as inhibition of TGF-beta-stimulated... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1115707

实验名称：Reduction in albuminuria in STZ-induced Ren2 rat at 400 mg/kg/day after 24 hrs by rad... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1115713

实验名称：Reduction in albuminuria in STZ-induced Ren2 rat at 200 mg/kg/day after 24 hrs by rad... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1115712

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FT011英文别名

• 2-({(2E)-3-[3-Methoxy-4-(2-propyn-1-yloxy)phenyl]-2-propenoyl}amino)benzoic acid