BC-1382

• 常用名: BC-1382
• 英文名: BC-1382
• CAS号: 1013753-99-5
• 分子量: 459.559
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₃H₂₉N₃O₅S
• 熔点: N/A
• 闪点: N/A

BC-1382用途

一种有效的泛素E3连接酶HECTD2抑制剂,特异性破坏HECTD2/PIAS1与IC50的相互作用5 nM；显着增加PIAS1蛋白水平,IC50为100 nM,改善PIAS1蛋白稳定性,对PIAS3,PIAS4和HECTD2蛋白没有影响水平；抑制LPS诱导的PIAS1降解并恢复800nM的PIAS1蛋白水平,以及PBMC释放的促炎细胞因子；减弱LPS-和铜绿假单胞菌诱导的肺部炎症

BC-1382名称

• 中文名: N-{(2S)-1-[(2-methoxybenzyl)amino]-1-oxopropan-2-yl}-1-(phenylsulfonyl)piperidine-4-carboxamide
• 英文名: N-{(2S)-1-[(2-Methoxybenzyl)amino]-1-oxo-2-propanyl}-1-(phenylsulfonyl)-4-piperidinecarboxamide

BC-1382生物活性

• 描述: 一种有效的泛素E3连接酶HECTD2抑制剂,特异性破坏HECTD2/PIAS1与IC50的相互作用5 nM；显着增加PIAS1蛋白水平,IC50为100 nM,改善PIAS1蛋白稳定性,对PIAS3,PIAS4和HECTD2蛋白没有影响水平；抑制LPS诱导的PIAS1降解并恢复800nM的PIAS1蛋白水平,以及PBMC释放的促炎细胞因子；减弱LPS-和铜绿假单胞菌诱导的肺部炎症
• 参考文献: References 1. Coon TA, et al. Sci Transl Med. 2015 Jul 8;7(295):295ra109. View Related Products by Target E3 Ubiquitin Ligase

BC-1382物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₃H₂₉N₃O₅S
• 分子量: 459.559
• 精确质量: 459.182800
• LogP: 2.13
• InChIKey: RCWXKFCEGKXUIN-KRWDZBQOSA-N
• SMILES: COc1ccccc1CNC(=O)C(C)NC(=O)C1CCN(S(=O)(=O)c2ccccc2)CC1
• 折射率: 1.584
• 储存条件: 2-8°C，密封，干燥

BC-1382安全信息

• 危害码 (欧洲): Xi

BC-1382靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

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BC-1382英文别名

• N-{(2S)-1-[(2-Methoxybenzyl)amino]-1-oxo-2-propanyl}-1-(phenylsulfonyl)-4-piperidinecarboxamide
• MFCD08290616
• MFCD30470656