2,4-双(4-吗啉基)-6-氯嘧啶结构式
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常用名 | 2,4-双(4-吗啉基)-6-氯嘧啶 | 英文名 | 4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine |
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| CAS号 | 10244-24-3 | 分子量 | 284.742 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 508.7±60.0 °C at 760 mmHg | |
| 分子式 | C12H17ClN4O2 | 熔点 | 139-142℃ | |
| MSDS | N/A | 闪点 | 261.5±32.9 °C |
| 中文名 | 2,4-双(4-吗啉基)-6-氯嘧啶 |
|---|---|
| 英文名 | 4,4'-(6-Chloropyrimidine-2,4-diyl)dimorpholine |
| 英文别名 | 更多 |
| 密度 | 1.3±0.1 g/cm3 |
|---|---|
| 沸点 | 508.7±60.0 °C at 760 mmHg |
| 熔点 | 139-142℃ |
| 分子式 | C12H17ClN4O2 |
| 分子量 | 284.742 |
| 闪点 | 261.5±32.9 °C |
| 精确质量 | 284.104004 |
| PSA | 50.72000 |
| LogP | 0.83 |
| InChIKey | KIWUTYCMQNZUPX-UHFFFAOYSA-N |
| SMILES | Clc1cc(N2CCOCC2)nc(N2CCOCC2)n1 |
| 蒸汽压 | 0.0±1.3 mmHg at 25°C |
| 折射率 | 1.576 |
| 储存条件 | 2-8°C |
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~92%
2,4-双(4-吗啉基)-6-氯嘧啶 10244-24-3 |
| 文献:NOVARTIS AG; CALIENNI, John Vincent; DE LA CRUZ, Marilyn; FLUBACHER, Dietmar; GONG, Baoqing; KAPA, Prasad Koteswara; KARPINSKI, Piotr H.; LIU, Hui; MICHEL, Pascal; MOSE, Rasmus; TESTA, Maria Caterina; WAYKOLE, Liladhar Murlidhar Patent: WO2012/44727 A2, 2012 ; Location in patent: Page/Page column 62-63 ; |
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~98%
2,4-双(4-吗啉基)-6-氯嘧啶 10244-24-3 |
| 文献:Burger, Matthew T.; Pecchi, Sabina; Wagman, Allan; Ni, Zhi-Jie; Knapp, Mark; Hendrickson, Thomas; Atallah, Gordana; Pfister, Keith; Zhang, Yanchen; Bartulis, Sarah; Frazier, Kelly; Ng, Simon; Smith, Aaron; Verhagen, Joelle; Haznedar, Joshua; Huh, Kay; Iwanowicz, Ed; Xin, Xiaohua; Menezes, Daniel; Merritt, Hanne; Lee, Isabelle; Wiesmann, Marion; Kaufman, Susan; Crawford, Kenneth; Chin, Michael; Bussiere, Dirksen; Shoemaker, Kevin; Zaror, Isabel; Maira, Sauveur-Michel; Voliva, Charles F. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 10 p. 774 - 779 |
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~57%
2,4-双(4-吗啉基)-6-氯嘧啶 10244-24-3
详细
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| 文献:WO2008/98058 A1, ; Page/Page column 57-58 ; WO 2008/098058 A1 |
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~78%
2,4-双(4-吗啉基)-6-氯嘧啶 10244-24-3 |
| 文献:ACS Medicinal Chemistry Letters, , vol. 2, # 10 p. 774 - 779 |
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~%
2,4-双(4-吗啉基)-6-氯嘧啶 10244-24-3 |
| 文献:WO2007/84786 A1, ; Page/Page column 123 ; WO 2007/084786 A1 |
| 2,4-双(4-吗啉基)-6-氯嘧啶上游产品 3 | |
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| 2,4-双(4-吗啉基)-6-氯嘧啶下游产品 1 | |
| 海关编码 | 2934999090 |
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| 中文概述 | 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途 |
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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实验名称:Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
来源:ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标:HCMV UL50
External Id:HMS1262
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实验名称:Small-molecule inhibitors of ST2 (IL1RL1)
来源:20881
靶标:interleukin-1 receptor-like 1 isoform [homo sapiens]
External Id:ST2_IL33_Inhibitors_Primary_Screening_77700
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实验名称:Inhibitors of CDC25B-CDK2/CyclinA interaction
来源:Center for Chemical Genomics, University of Michigan
External Id:MScreen:TargetID_600
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实验名称:High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ...
来源:ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id:HMS1303
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实验名称:Cell-based high throughput primary assay to identify activators of GPR151
来源:The Scripps Research Institute Molecular Screening Center
靶标:RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL
External Id:GPR151_PHUNTER_AG_LUMI_1536_1X%ACT
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实验名称:AlphaScreen-based biochemical high throughput primary assay to identify activators of...
来源:The Scripps Research Institute Molecular Screening Center
靶标:N/A
External Id:FBW7_ACT_ALPHA_1536_1X%ACT PRUN
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实验名称:AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of...
来源:The Scripps Research Institute Molecular Screening Center
External Id:MITF_INH_Alpha_1536_1X%INH PRUN
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| 4,4'-(6-Chloro-2,4-pyrimidinediyl)dimorpholine |
| 4-(4-chloro-6-morpholin-4-ylpyrimidin-2-yl)morpholine |