(±)-5'-氯-5'-脱氧-ENBA

• 常用名: (±)-5'-氯-5'-脱氧-ENBA
• 英文名: (±)-5'-Chloro-5'-deoxy-ENBA
• CAS号: 103626-26-2
• 分子量: 379.84100
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₂₂ClN₅O₃
• 熔点: N/A
• 闪点: N/A

(±)-5'-氯-5'-脱氧-ENBA用途

(±)-5'-Chloro-5'-deoxy-ENBA 是 A1AR 的激动剂。(±)-5'-Chloro-5'-deoxy-ENBA 导致小鼠体温过低。

(±)-5'-氯-5'-脱氧-ENBA名称

• 中文名: N-双环[2.2.1]-2-庚基-5-氯-5-脱氧腺苷酸
• 英文名: (2R,3R,4S,5S)-2-[6-(3-bicyclo[2.2.1]heptanylamino)purin-9-yl]-5-(chloromethyl)oxolane-3,4-diol

(±)-5'-氯-5'-脱氧-ENBA生物活性

• 描述: (±)-5'-Chloro-5'-deoxy-ENBA 是 A1AR 的激动剂。(±)-5'-Chloro-5'-deoxy-ENBA 导致小鼠体温过低。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体
• 参考文献:

  [1]. Province HS, et al. Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms. PLoS One. 2020 Dec 16;15(12):e0243986.

(±)-5'-氯-5'-脱氧-ENBA物理化学性质

• 分子式: C₁₇H₂₂ClN₅O₃
• 分子量: 379.84100
• 精确质量: 379.14100
• PSA: 105.32000
• LogP: 1.35780
• InChIKey: PVJGDYDNVNCGBT-STHLEMNDSA-N
• SMILES: OC1C(CCl)OC(n2cnc3c(NC4CC5CCC4C5)ncnc32)C1O

(±)-5'-氯-5'-脱氧-ENBA靶点实验

查看更多实验

实验名称：Antagonist activity at human recombinant adenosine A3 receptor expressed in CHO cells... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL1016191

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Lipophilicity log P of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL1016190

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Selectivity of Ki for human recombinant adenosine A2A receptor to Ki for human recomb... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1015332

实验名称：Selectivity of Ki for human recombinant adenosine A3 receptor to Ki for human recombi... 来源：ChEMBL 靶标：Adenosine receptors; A1 & A3 External Id：CHEMBL1015333

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(±)-5'-氯-5'-脱氧-ENBA英文别名

• 5'Cl5'd-ENBA
• 5'-chloro-5'-deoxy-N6-(endo-norborn-2-yl)adenosine
• (+/-)-5'-Chloro-5'-deoxy-ENBA
• SDZ SER 082 fumarate