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α,β-亚甲基腺苷 5'-二磷酸 钠盐

更新时间:2025-09-04 19:11:57

α,β-亚甲基腺苷 5'-二磷酸 钠盐结构式
α,β-亚甲基腺苷 5'-二磷酸 钠盐结构式
品牌特惠专场
常用名 α,β-亚甲基腺苷 5'-二磷酸 钠盐 英文名 ALPHA,BETA-METHYLENEADENOSINE 5'-DIPHOSPHATE SODIUM SALT
CAS号 104835-70-3 分子量 469.19200
密度 N/A 沸点 N/A
分子式 C11H15N5Na2O9P2 熔点 N/A
MSDS 美版 闪点 N/A

 用途


αβ-亚甲基腺苷5′-二磷酸(AMP-CP)是ADP类似物,具有抑制胞外核苷酸酶/CD73 的能力,通过CD73/胞外-5′-核苷酸酶,用于研究腺苷能信号调控。

 名称

中文名 Α,Β-亚甲基腺苷 5'-二磷酸钠盐
英文名 α,β-METHYLENEADENOSINE 5'-DIPHOSPHATE SODIUM SALT
英文别名 更多

 物理化学性质

分子式 C11H15N5Na2O9P2
分子量 469.19200
精确质量 469.01400
PSA 248.65000
InChIKey XBMIJZIUIGRFDM-LYYWGVPGSA-L
SMILES Nc1ncnc2c1ncn2C1OC(COP(=O)([O-])CP(=O)([O-])O)C(O)C1O.[Na+].[Na+]
外观性状 固体
储存条件 20°C

 安全信息

危害码 (欧洲) Xi: Irritant;
风险声明 (欧洲) 36/37/38
安全声明 (欧洲) 26-36
危险品运输编码 NONH for all modes of transport

 文献4

更多文献
IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier.

Eur. J. Immunol. 38 , 2718-2726, (2008)

IFN-beta treatment reduces the relapse rate in MS but its mechanism of action remains incompletely understood. Our aim was to clarify the beneficial effect of IFN-beta in the treatment of MS. We asses...

Altered purinergic signaling in CD73-deficient mice inhibits tumor progression.

Eur. J. Immunol. 41 , 1231-1241, (2011)

CD73/ecto-5'-nucleotidase dephosphorylates extracellular AMP into adenosine, and it is a key enzyme in the regulation of adenosinergic signaling. The contribution of host CD73 to tumor growth and anti...

Studies of the extracellular ATP-adenosine pathway in human urinary tract epithelial cells.

Pharmacology 84 , 196-202, (2009)

Extracellular ATP may be metabolized to AMP and adenosine by the ectonucleotidases CD39 and CD73 and, in this study, we characterized the pathways for adenosine formation in human urinary tract epithe...

 靶点实验

查看更多实验

实验名称:Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
来源:NCGC
靶标:N/A
External Id:SERCaMPGLuc-p1-antagonist
实验名称:Luminescence-based cell-based primary high throughput screening assay to identify ago...
来源:The Scripps Research Institute Molecular Screening Center
靶标:mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id:OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
实验名称:QFRET-based biochemical primary high throughput screening assay to identify exosite i...
来源:The Scripps Research Institute Molecular Screening Center
靶标:disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id:ADAM17_INH_QFRET_1536_1X%INH PRUN
实验名称:Fluorescence-based cell-based primary high throughput screening assay to identify ago...
来源:The Scripps Research Institute Molecular Screening Center
靶标:muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id:CHRM1_AG_FLUO8_1536_1X%ACT PRUN
实验名称:Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
来源:Broad Institute
靶标:FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id:2147-01_Inhibitor_SinglePoint_HTS_Activity
实验名称:Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
来源:Broad Institute
靶标:N/A
External Id:Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
实验名称:Inhibition of recombinant human ENPP1 using ATP as substrate assessed as inhibition c...
来源:ChEMBL
靶标:Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
External Id:CHEMBL5513804
实验名称:Fluorescence-based cell-based primary high throughput screening assay to identify pos...
来源:The Scripps Research Institute Molecular Screening Center
靶标:muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id:CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
实验名称:Fluorescence polarization-based biochemical high throughput primary assay to identify...
来源:The Scripps Research Institute Molecular Screening Center
靶标:RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id:SIAE_INH_FP_1536_1X%INH PRUN
实验名称:Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (E...
来源:NCGC
External Id:epac1-activator-v
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 英文别名

AMP-CP SODIUM SALT
A,B-methyleneadenosine 5'-diphosphate*sodium
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