SUN13837

• 常用名: SUN13837
• 英文名: SUN13837
• CAS号: 1080650-67-4
• 分子量: 383.49
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₉N₅O₂
• 熔点: N/A
• 闪点: N/A

SUN13837用途

SUN13837是一种口服活性、有效且BBB穿透的FGFR(成纤维细胞生长因子受体)调节剂。SUN13837具有神经保护活性。SUN13837可用于神经退行性疾病研究[1]。

SUN13837名称

• 英文名: SUN13837

SUN13837生物活性

• 描述: SUN13837是一种口服活性、有效且BBB穿透的FGFR(成纤维细胞生长因子受体)调节剂。SUN13837具有神经保护活性。SUN13837可用于神经退行性疾病研究[1]。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> FGFR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Sakai H, et al. Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential. Bioorg Med Chem. 2020 Jul 15;28(14):115562.

SUN13837物理化学性质

• 分子式: C₂₁H₂₉N₅O₂
• 分子量: 383.49

SUN13837靶点实验

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实验名称：Oral bioavailability in Crl:CD(SD) rat at 10 mg/kg by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4624982

实验名称：Ratio of drug level in Crl:CD(SD) rat brain to plasma at 1 mg/kg, iv measured after 1... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4624984

实验名称：Permeability of the compound at 10 uM at pH 7.4 incubated for 2 hrs by PAMPA assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL4624986

实验名称：Efflux ratio of apparent permeability in human Caco2 cells at 10 uM incubated for 120... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4624985

实验名称：Drug metabolism in human liver microsomes assessed as carboxylesterase-mediated hydro... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4624987

实验名称：Volume of distribution in Crl:CD(SD) rat at 1 mg/kg, iv by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4624973

实验名称：Mechanism based inactivation of CYP3A4 in human liver microsome assessed as remaining... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4624976

实验名称：Partition coefficient, logP of compound by RP-HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4624975

实验名称：Elimination half life in Crl:CD(SD) rat at 1 mg/kg, iv by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4624978

实验名称：Inhibition of CYP3A4 in human liver microsomes assessed as enzyme residual activity a... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4390437

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