12-OxoETE

• 常用名: 12-OxoETE
• 英文名: 12-OxoETE
• CAS号: 108437-64-5
• 分子量: 318.450
• 密度: 1.0±0.1 g/cm3
• 沸点: 494.9±45.0 °C at 760 mmHg
• 分子式: C₂₀H₃₀O₃
• 熔点: N/A
• 闪点: 267.2±25.2 °C

12-OxoETE用途

12-氧酯通过白三烯B4受体或一个共同的激活序列诱导细胞质游离钙的快速、剂量依赖性增加[1][2]。

12-OxoETE名称

• 英文名: 12-oxo-ETE

12-OxoETE生物活性

• 描述: 12-氧酯通过白三烯B4受体或一个共同的激活序列诱导细胞质游离钙的快速、剂量依赖性增加[1][2]。
• 相关类别:
  研究领域 >> 炎症/免疫
• 靶点实验:

  Human Endogenous Metabolite

• 参考文献:

  [1]. Naccache PH, Leblanc Y, Rokach J, Patrignani P, Fruteau de Laclos B, Borgeat P. Calcium mobilization and right-angle light scatter responses to 12-oxo-derivatives of arachidonic acid in neutrophils: evidence for the involvement of the leukotriene B4 receptor. Biochim Biophys Acta. 1991 Dec 3;1133(1):102-6.

12-OxoETE物理化学性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 494.9±45.0 °C at 760 mmHg
• 分子式: C₂₀H₃₀O₃
• 分子量: 318.450
• 闪点: 267.2±25.2 °C
• 精确质量: 318.219482
• PSA: 54.37000
• LogP: 5.18
• InChIKey: GURBRQGDZZKITB-GVIPNGEASA-N
• SMILES: CCCCCC=CCC(=O)C=CC=CCC=CCCCC(=O)O
• 蒸汽压: 0.0±2.7 mmHg at 25°C
• 折射率: 1.506
• 储存条件: -20°C

12-OxoETE靶点实验

查看更多实验

实验名称：Irreversible inhibition of human reticulocyte 15-lipoxygenase-1 by assessed as rate o... 来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX15 External Id：CHEMBL3374570

实验名称：Selectivity for human reticulocyte 15-lipoxygenase-1 over human platelet 12-lipoxygen... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3374568

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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12-OxoETE英文别名

• (5Z,8Z,10E,14Z)-12-Oxo-5,8,10,14-icosatetraenoic acid
• 12-Oxo-ETE
• 12-Oxo-5Z,8Z,10E,14Z-eicosatetraenoic acid
• 12-oxoicosa-5,8,10,14-tetraenoic acid