Linopirdine dihydrochloride

• 常用名: Linopirdine dihydrochloride
• 英文名: Linopirdine dihydrochloride
• CAS号: 113168-57-3
• 分子量: 464.386
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₁N₃O_.2HCl
• 熔点: N/A
• 闪点: N/A

Linopirdine dihydrochloride用途

Linopirdine(DUP-996)是一种有效的Kv7(KCNQ)电压门控钾通道blcoker；阻断Kv7.1+7.3(KCNQ2+3)/M电流(IC50=4-7 uM)和Kv7.1(KCNQ1)同源通道(IC50=8.9 uM)；抑制M型K+电流,增加大鼠海马CA1神经元中乙酰胆碱的释放；体内活性。阿尔茨海默病第1阶段停止

Linopirdine dihydrochloride名称

• 中文名: 盐酸利诺吡定
• 英文名: 1-Phenyl-3,3-bis(4-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one dihydrochloride

Linopirdine dihydrochloride生物活性

• 描述: Linopirdine(DUP-996)是一种有效的Kv7(KCNQ)电压门控钾通道blcoker；阻断Kv7.1+7.3(KCNQ2+3)/M电流(IC50=4-7 uM)和Kv7.1(KCNQ1)同源通道(IC50=8.9 uM)；抑制M型K+电流,增加大鼠海马CA1神经元中乙酰胆碱的释放；体内活性。阿尔茨海默病第1阶段停止
• 参考文献: References 1. Schnee ME, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17. 2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3. 3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30. View Related Products by Target Potassium Channel Alzheimer Disease

Linopirdine dihydrochloride物理化学性质

• 分子式: C₂₆H₂₁N₃O_.2HCl
• 分子量: 464.386
• 精确质量: 463.121826
• InChIKey: ZEVVHCGTTNRYOY-UHFFFAOYSA-N
• SMILES: Cl.Cl.O=C1N(c2ccccc2)c2ccccc2C1(Cc1ccncc1)Cc1ccncc1
• 储存条件: 2-8°C

Linopirdine dihydrochloride靶点实验

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实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

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Linopirdine dihydrochloride英文别名

• 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one dihydrochloride
• 1-Phenyl-3,3-bis(4-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one dihydrochloride
• 2H-Indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-, hydrochloride (1:2)
• MFCD06245587