Linopirdine dihydrochloride

• 常用名: Linopirdine dihydrochloride
• 英文名: Linopirdine dihydrochloride
• CAS号: 113168-57-3
• 分子量: 464.386
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₁N₃O_.2HCl
• 熔点: N/A
• 闪点: N/A

Linopirdine dihydrochloride用途

Linopirdine(DUP-996)是一种有效的Kv7(KCNQ)电压门控钾通道blcoker；阻断Kv7.1+7.3(KCNQ2+3)/M电流(IC50=4-7 uM)和Kv7.1(KCNQ1)同源通道(IC50=8.9 uM)；抑制M型K+电流,增加大鼠海马CA1神经元中乙酰胆碱的释放；体内活性。阿尔茨海默病第1阶段停止

Linopirdine dihydrochloride名称

• 中文名: 盐酸利诺吡定
• 英文名: 1-Phenyl-3,3-bis(4-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one dihydrochloride

Linopirdine dihydrochloride生物活性

• 描述: Linopirdine(DUP-996)是一种有效的Kv7(KCNQ)电压门控钾通道blcoker；阻断Kv7.1+7.3(KCNQ2+3)/M电流(IC50=4-7 uM)和Kv7.1(KCNQ1)同源通道(IC50=8.9 uM)；抑制M型K+电流,增加大鼠海马CA1神经元中乙酰胆碱的释放；体内活性。阿尔茨海默病第1阶段停止
• 参考文献: References 1. Schnee ME, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17. 2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3. 3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30. View Related Products by Target Potassium Channel Alzheimer Disease

Linopirdine dihydrochloride物理化学性质

• 分子式: C₂₆H₂₁N₃O_.2HCl
• 分子量: 464.386
• 精确质量: 463.121826
• 储存条件: 2-8°C

Linopirdine dihydrochloride英文别名

• 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one dihydrochloride
• 1-Phenyl-3,3-bis(4-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one dihydrochloride
• 2H-Indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-, hydrochloride (1:2)
• MFCD06245587