Linopirdine dihydrochloride
Modify Date: 2024-07-20 18:49:21
Linopirdine dihydrochloride structure
|
Common Name | Linopirdine dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 113168-57-3 | Molecular Weight | 464.386 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H21N3O.2HCl | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Linopirdine dihydrochlorideLinopirdine (DUP-996) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM); inhibits M-type K+ current, increases acetylcholine release in rat hippocampal CA1 neurons; active in vivo. Alzheimer Disease Phase 1 Discontinued |
| Name | 1-Phenyl-3,3-bis(4-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one dihydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Linopirdine (DUP-996) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM); inhibits M-type K+ current, increases acetylcholine release in rat hippocampal CA1 neurons; active in vivo. Alzheimer Disease Phase 1 Discontinued |
|---|---|
| References | References 1. Schnee ME, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17. 2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3. 3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30. View Related Products by Target Potassium Channel Alzheimer Disease |
| Molecular Formula | C26H21N3O.2HCl |
|---|---|
| Molecular Weight | 464.386 |
| Exact Mass | 463.121826 |
| Storage condition | 2-8°C |
| 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one dihydrochloride |
| 1-Phenyl-3,3-bis(4-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one dihydrochloride |
| 2H-Indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-, hydrochloride (1:2) |
| MFCD06245587 |