2-(4-(2-(三氟甲基)苯基)哌啶-1-甲酰胺基)苯甲酸

• 常用名: 2-(4-(2-(三氟甲基)苯基)哌啶-1-甲酰胺基)苯甲酸
• 英文名: A 1120
• CAS号: 1152782-19-8
• 分子量: 392.37
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₉F₃N₂O₃
• 熔点: N/A
• 闪点: N/A

用途

A 1120 是一种与视黄醇结合蛋白 4 (RBP4) 高亲和力结合的非视黄醇配体,ki 值为 8.3 nM。

名称

• 中文名: A 1120
• 英文名: 2-[({4-[2-(Trifluoromethyl)phenyl]-1-piperidinyl}carbonyl)amino]b enzoic acid

生物活性

• 描述: A 1120 是一种与视黄醇结合蛋白 4 (RBP4) 高亲和力结合的非视黄醇配体,ki 值为 8.3 nM。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 靶点实验:

  ki: 8.3 nM (Retinol-binding protein 4)[1]

• 体外研究: A 1120的IC50对人RBP4为90 nM,对小鼠RBP4为66 nM [1]。
• 参考文献:

  [1]. Motani A, et al. Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J Biol Chem. 2009 Mar 20;284(12):7673-80.

物理化学性质

• 分子式: C₂₀H₁₉F₃N₂O₃
• 分子量: 392.37
• 精确质量: 392.13500
• PSA: 73.13000
• LogP: 4.76660
• InChIKey: MEAQCLPMSVEOQF-UHFFFAOYSA-N
• SMILES: O=C(O)c1ccccc1NC(=O)N1CCC(c2ccccc2C(F)(F)F)CC1
• 外观性状: 棕褐色固体
• 储存条件: 2-8°C，干燥，密闭

安全信息

• 危害码 (欧洲): Xi

靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Displacement of [3H]retinol from biotinylated human RBP4 by scintillation proximity a... 来源：ChEMBL 靶标：Retinol-binding protein 4 External Id：CHEMBL3380009

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Metabolic stability in human liver microsomes assessed as compound remaining at 10 uM... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3380011

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed... 来源：ChEMBL 靶标：Retinol-binding protein 4 External Id：CHEMBL3380010

实验名称：Aqueous kinetic solubility of the compound in pH 7.4 PBS buffer 来源：ChEMBL 靶标：N/A External Id：CHEMBL3380638

实验名称：Metabolic stability in rat liver microsomes assessed as compound remaining at 10 uM a... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3380637

实验名称：Inhibition of CYP2C19 (unknown origin) 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL3380640

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英文别名

• N-Arachidonylglycine