4-Hydroxymephenytoin D3

• 常用名: 4-Hydroxymephenytoin D3
• 英文名: (+/-)-4-Hydroxy Mephenytoin-d3
• CAS号: 1173022-56-4
• 分子量: 237.270
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₂H₁₁D₃N₂O₃
• 熔点: N/A
• 闪点: N/A

4-Hydroxymephenytoin D3用途

4-羟基苯妥英D3是氘标记的4-羟基苯妥英。4-羟基苯妥英钠是抗癫痫药物苯妥英钠的代谢产物,用作CYP2C19底物[1][2]。

4-Hydroxymephenytoin D3名称

• 英文名: 5-ethyl-5-(4-hydroxyphenyl)-3-(trideuteriomethyl)imidazolidine-2,4-dione

4-Hydroxymephenytoin D3生物活性

• 描述: 4-羟基苯妥英D3是氘标记的4-羟基苯妥英。4-羟基苯妥英钠是抗癫痫药物苯妥英钠的代谢产物,用作CYP2C19底物[1][2]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Tanaka M, et al. Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test. J Chromatogr B Biomed Appl. 1996 Feb 9;676(1):87-94.

  [3]. Stewart NA, et al. A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution. Analyst. 2011 Feb 7;136(3):605-12.

4-Hydroxymephenytoin D3物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₁₂H₁₁D₃N₂O₃
• 分子量: 237.270
• 精确质量: 237.119278
• PSA: 73.13000
• LogP: 0.66
• InChIKey: OQPLORUDZLXXPD-BMSJAHLVSA-N
• SMILES: CCC1(c2ccc(O)cc2)NC(=O)N(C)C1=O
• 折射率: 1.568

4-Hydroxymephenytoin D3英文别名

• p-Hydroxymephenytoin-d3
• 5-Ethyl-5-(4-hydroxyphenyl)-3-(H)methyl-2,4-imidazolidinedione