(+/-)-4-Hydroxy Mephenytoin-d3

Modify Date: 2024-01-11 05:52:45

(+/-)-4-Hydroxy Mephenytoin-d3 structure	Common Name	(+/-)-4-Hydroxy Mephenytoin-d3
	CAS Number	1173022-56-4	Molecular Weight	237.270
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₁D₃N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (+/-)-4-Hydroxy Mephenytoin-d3

4-Hydroxymephenytoin D3 is the deuterium labeled 4-Hydroxymephenytoin. 4-Hydroxymephenytoin is a metabolism of an antiepileptic drug mephenytoin, which is used as a CYP2C19 substrate[1][2].

Name	5-ethyl-5-(4-hydroxyphenyl)-3-(trideuteriomethyl)imidazolidine-2,4-dione
Synonym	More Synonyms

Description	4-Hydroxymephenytoin D3 is the deuterium labeled 4-Hydroxymephenytoin. 4-Hydroxymephenytoin is a metabolism of an antiepileptic drug mephenytoin, which is used as a CYP2C19 substrate[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Tanaka M, et al. Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test. J Chromatogr B Biomed Appl. 1996 Feb 9;676(1):87-94. [3]. Stewart NA, et al. A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution. Analyst. 2011 Feb 7;136(3):605-12.

Density	1.3±0.1 g/cm3
Molecular Formula	C₁₂H₁₁D₃N₂O₃
Molecular Weight	237.270
Exact Mass	237.119278
PSA	73.13000
LogP	0.66
Index of Refraction	1.568

p-Hydroxymephenytoin-d3

5-Ethyl-5-(4-hydroxyphenyl)-3-(H)methyl-2,4-imidazolidinedione

2,4-Imidazolidinedione, 5-ethyl-5-(4-hydroxyphenyl)-3-(methyl-d)-

(+/-)-4-Hydroxy Mephenytoin-d3

Use of (+/-)-4-Hydroxy Mephenytoin-d3

Names

(+/-)-4-Hydroxy Mephenytoin-d3 Biological Activity

Chemical & Physical Properties

Synonyms