ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER

更新时间：2024-01-02 19:00:36

ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER结构式	常用名	ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER	英文名	CRF (6-33)
	CAS号	120066-38-8	分子量	3220.66000
	密度	N/A	沸点	N/A
	分子式	C₁₄₁H₂₃₁N₄₁O₄₃S	熔点	N/A
	MSDS	美版	闪点	N/A

用途

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CRF(6-33)(human) 是一种 CRF 结合蛋白配体 (CRF-BP) 抑制剂,与 CRF-BP 竞争性结合,但不与突触后 CRF 受体结合。CRF(6-33)(human) 具有抗肥胖作用。

中文名	ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER
英文名	Corticotropin Releasing Factor Fragment 6-33 human, rat
英文别名	更多

描述	CRF(6-33)(human) 是一种 CRF 结合蛋白配体 (CRF-BP) 抑制剂,与 CRF-BP 竞争性结合,但不与突触后 CRF 受体结合。CRF(6-33)(human) 具有抗肥胖作用。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> CRFR 研究领域 >> 神经疾病
参考文献	[1]. S C Heinrichs, et al. Dissociation of arousal-like from anxiogenic-like actions of brain corticotropin-releasing factor receptor ligands in rats. Behav Brain Res. 2001 Jul;122(1):43-50. [2]. S C Heinrichs, et al. Selective stimulatory actions of corticotropin-releasing factor ligands on correlates of energy balance. Physiol Behav. 2001 Sep 1-15;74(1-2):5-13.

描述

CRF(6-33)(human) 是一种 CRF 结合蛋白配体 (CRF-BP) 抑制剂,与 CRF-BP 竞争性结合,但不与突触后 CRF 受体结合。CRF(6-33)(human) 具有抗肥胖作用。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> CRFR

研究领域 >> 神经疾病

参考文献

[1]. S C Heinrichs, et al. Dissociation of arousal-like from anxiogenic-like actions of brain corticotropin-releasing factor receptor ligands in rats. Behav Brain Res. 2001 Jul;122(1):43-50.

[2]. S C Heinrichs, et al. Selective stimulatory actions of corticotropin-releasing factor ligands on correlates of energy balance. Physiol Behav. 2001 Sep 1-15;74(1-2):5-13.

分子式	C₁₄₁H₂₃₁N₄₁O₄₃S
分子量	3220.66000
精确质量	3218.69000
PSA	1394.64000
LogP	3.96850
外观性状	固体
储存条件	2-8°C，密封，干燥

MSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
WGK德国	3

Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders.

Mol. Psychiatry 1 , 265-277, (1996)

The actions of CRF in the brain and in the periphery are mediated through multiple binding sites. There are three receptors, CRF1, CRF2 alpha and CRF2 beta, which encode 411, 415 and 431 amino acid pr...

Corticotropin-releasing factor-binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicotine withdrawal.

Proc. Natl. Acad. Sci. U. S. A. 93 , 15475-15480, (1996)

Elevation of the neuropeptide corticotropin-releasing factor (CRF) in the brain is associated with a reduction of food intake and body weight gain in normal and obese animals. A protein that binds CRF...

MFCD00671436