RO-24-0238

• 常用名: RO-24-0238
• 英文名: Ro-24-0238
• CAS号: 120555-31-9
• 分子量: 420.58700
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₃₆N₂O₂
• 熔点: N/A
• 闪点: N/A

RO-24-0238用途

Ro-24-0238 是一种有效的 platelet activating factor (PAF) 拮抗剂和 thromboxane synthesis 的抑制剂,可用于减轻由血小板活化因子得释放导致的炎症和损伤。

RO-24-0238名称

• 中文名: RO-24-0238
• 英文名: Ro 24-0238

RO-24-0238生物活性

• 描述: Ro-24-0238 是一种有效的 platelet activating factor (PAF) 拮抗剂和 thromboxane synthesis 的抑制剂,可用于减轻由血小板活化因子得释放导致的炎症和损伤。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体内研究: 用3mg/kg Ro 24-0238和3mg/kg WEB 2086预处理可减少大鼠粘膜内中性粒细胞的积累[1]。
• 参考文献:

  [1]. Will PC, et al. Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat. Agents Actions. 1991 Sep;34(1-2):181-4.

RO-24-0238物理化学性质

• 分子式: C₂₇H₃₆N₂O₂
• 分子量: 420.58700
• 精确质量: 420.27800
• PSA: 51.22000
• LogP: 6.52860
• InChIKey: HLCHRSFXEXAMLU-YDQNRGGDSA-N
• SMILES: CCCCCC(=CC=CC(=O)NC(C)CCCc1cccnc1)c1ccc(OC)cc1
• 储存条件: 2-8℃

RO-24-0238靶点实验

查看更多实验

实验名称：PAF-induced capillary permeability changes are studied in rat skin test, after intrav... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL878805

实验名称：Ability to prevent PAF-induced bronchoconstriction in guinea pig 6 hr following 50 mg... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL684648

实验名称：Ability to prevent PAF-induced bronchoconstriction in guinea pig when administered at... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL684650

实验名称：PAF-induced capillary permeability changes are studied in rat skin test, after perora... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL788000

实验名称：PAF-induced capillary permeability changes are studied in guinea pig skin test, after... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL686374

实验名称：Inhibition of PAF-induced bronchoconstriction in the guinea pig, (1 mg/kg) intravenou... 来源：ChEMBL 靶标：Platelet-activating factor receptor External Id：CHEMBL681491

实验名称：PAF-induced capillary permeability changes are studied in guinea pig test, after intr... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL686375

实验名称：Inhibition of PAF-induced bronchoconstriction in the guinea pig after 1 mg/kg p.o. ad... 来源：ChEMBL 靶标：Platelet-activating factor receptor External Id：CHEMBL681493

实验名称：Ability to prevent PAF-induced bronchoconstriction in guinea pig when administered in... 来源：ChEMBL 靶标：Platelet-activating factor receptor External Id：CHEMBL684008

实验名称：Inhibition of PAF-induced bronchoconstriction in guinea pig after oral administration... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL688102

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RO-24-0238英文别名

• (R)-(2E,4E)-5-(4-methoxyphenyl)-N-[1-methyl-4-(3-pyridinyl)butyl]-2,4-decadienamide
• [R-(E,E)]-5-(4-methoxyphenyl)-N-[1-methyl-4-(3-pyridinyl)butyl]-2.4-decadienamide
• (2E,4E)-5-(4-Methoxy-phenyl)-deca-2,4-dienoic acid ((R)-1-methyl-4-pyridin-3-yl-butyl)-amide
• <R-(E,E)>-5-(4-methoxyphenyl)-N-<1-methyl-4-(3-pyridinyl)butyl>-2,4-decadienamide
• (R-(E,E))-5-(4-methoxyphenyl)-N-[1-methyl-4-(3-pyridinyl)butyl]-2,4-decadienamide
• Ro-24-0238