莫非吉兰

更新时间：2025-08-25 21:49:19

莫非吉兰结构式	常用名	莫非吉兰	英文名	Mofegiline hydrochloride
	CAS号	120635-25-8	分子量	233.685
	密度	N/A	沸点	322.7ºC at 760 mmHg
	分子式	C₁₁H₁₄ClF₂N	熔点	N/A
	MSDS	N/A	闪点	149ºC

莫非吉兰用途

Mofegiline(MDL72974A)盐酸盐是酶活化的不可逆MAO-B抑制剂,对MAO-A和MAO-B的IC50分别为680和3.6 nM。

中文名	莫非吉兰
英文名	(2E)-2-(fluoromethylidene)-4-(4-fluorophenyl)butan-1-amine,hydrochloride
英文别名	更多

描述	Mofegiline(MDL72974A)盐酸盐是酶活化的不可逆MAO-B抑制剂,对MAO-A和MAO-B的IC50分别为680和3.6 nM。
相关类别	信号通路 >> 神经信号通路 >> 单胺氧化酶研究领域 >> 神经疾病
参考文献	[1]. Zreika M, et al. MDL 72,974: a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson's disease. J Neural Transm Park Dis Dement Sect. 1989;1(4):243-54. [2]. Yu PH, et al. Inhibition of a type B monoamine oxidase inhibitor, (E)-2-(4-fluorophenethyl)-3-fluoroallylamine (MDL-72974A), on semicarbazide-sensitive amine oxidases isolated from vascular tissues and sera of different species. Biochem Pharmacol. 1992 Ja [3]. Dow J, et al. Novel carbamate metabolites of mofegiline, a primary amine monoamine oxidase B inhibitor, in dogs and humans. Drug Metab Dispos. 1994 Sep-Oct;22(5):738-49.

描述

Mofegiline(MDL72974A)盐酸盐是酶活化的不可逆MAO-B抑制剂,对MAO-A和MAO-B的IC50分别为680和3.6 nM。

相关类别

信号通路 >> 神经信号通路 >> 单胺氧化酶

研究领域 >> 神经疾病

参考文献

[1]. Zreika M, et al. MDL 72,974: a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson's disease. J Neural Transm Park Dis Dement Sect. 1989;1(4):243-54.

[2]. Yu PH, et al. Inhibition of a type B monoamine oxidase inhibitor, (E)-2-(4-fluorophenethyl)-3-fluoroallylamine (MDL-72974A), on semicarbazide-sensitive amine oxidases isolated from vascular tissues and sera of different species. Biochem Pharmacol. 1992 Ja

[3]. Dow J, et al. Novel carbamate metabolites of mofegiline, a primary amine monoamine oxidase B inhibitor, in dogs and humans. Drug Metab Dispos. 1994 Sep-Oct;22(5):738-49.

沸点	322.7ºC at 760 mmHg
分子式	C₁₁H₁₄ClF₂N
分子量	233.685
闪点	149ºC
精确质量	233.078278
PSA	26.02000
LogP	4.07270
InChIKey	QUCNNQHLIHGBIA-HCUGZAAXSA-N
SMILES	Cl.NCC(=CF)CCc1ccc(F)cc1
蒸汽压	0.00232mmHg at 25°C
储存条件	2-8℃

(E)-N-(2-(fluor...

177031-49-1

莫非吉兰

120635-25-8

文献：US5488188 A1, ;

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MOFEGILINE HYDROCHLORIDE

(E)-2-(p-fluorophenethyl)-3-fluoroallylamine hydrochloric acid

(2Z)-2-(Fluoromethylene)-4-(4-fluorophenyl)-1-butanamine hydrochloride (1:1)

(2Z)-3-Fluoro-2-[2-(4-fluorophenyl)ethyl]prop-2-en-1-amine Hydrochloride

MDL 72974A

Mofegiline hydrochloride (USAN)

Benzenebutanamine, 4-fluoro-β-(fluoromethylene)-, (βZ)-, hydrochloride (1:1)

Mofegiline HCl

(E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane hydrochloride salt