GLPG0492 R对映体

• 常用名: GLPG0492 R对映体
• 英文名: GLPG0492 (R enantiomer)
• CAS号: 1215085-93-0
• 分子量: 389.32800
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₄F₃N₃O₃
• 熔点: N/A
• 闪点: N/A

GLPG0492 R对映体用途

GLPG0492 R enantiomer是GLPG0492的R型对映体,GLPG0492是新型选择性SARM

GLPG0492 R对映体名称

• 中文名: GLPG0492 R对映体
• 英文名: (R)-(+)-4-[2,5-dioxo-4-(hydroxymethyl)-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

GLPG0492 R对映体生物活性

• 描述: GLPG0492 R enantiomer是GLPG0492的R型对映体,GLPG0492是新型选择性SARM
• 相关类别:
  信号通路 >> 其他 >> 雄激素受体
  研究领域 >> 其他
• 参考文献:

  [1]. Nique F, et al. Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator. J Med Chem. 2012 Oct 11;55(19):8236-47.

  [2]. Cozzoli A, et al. GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy. Pharmacol Res. 2013 Jun;72:9-24.

  [3]. Blanqué R, et al. Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization. BMC Musculoskelet Disord. 2014 Sep 3;15:291.

GLPG0492 R对映体物理化学性质

• 分子式: C₁₉H₁₄F₃N₃O₃
• 分子量: 389.32800
• 精确质量: 389.09900
• PSA: 84.64000
• LogP: 2.86618
• InChIKey: VAJGULUVTFDTAS-SFHVURJKSA-N
• SMILES: CN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(CO)c1ccccc1
• 储存条件: 2-8℃

GLPG0492 R对映体靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase... 来源：NCGC External Id：GPx1-biochemical-p4-p7

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

实验名称：Anabolic activity in ORX rat model assessed as weight of levator ani muscle at 10 mg/... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2188299

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GLPG0492 R对映体英文别名

• (R)-4-[2,5-dioxo-4-hydroxymethyl-3-methyl-4-phenylimidazolidin-1-yl]-2-trifluoromethylbenzonitrile
• GLPG0492 (R enantiomer)