JNJ-49095397

• 常用名: JNJ-49095397
• 英文名: JNJ-49095397
• CAS号: 1220626-82-3
• 分子量: 592.687
• 密度: 1.2±0.1 g/cm3
• 沸点: 738.0±60.0 °C at 760 mmHg
• 分子式: C₃₄H₃₆N₆O₄
• 熔点: N/A
• 闪点: 400.1±32.9 °C

JNJ-49095397用途

JNJ-49095397(RV-568)是一种特异性窄谱激酶抑制剂,可抑制一组参与COPD炎症的激酶,p38α,p38γ和HCK的IC50分别为5,40和52 nM；显示出有效的抗炎作用。在单核细胞和巨噬细胞中,证明了poly I:C刺激的BEAS-2B细胞和与皮质类固醇结合的香烟烟雾模型中的协同相互作用。COPD 2期临床

JNJ-49095397名称

• 英文名: Jnj-49095397

JNJ-49095397生物活性

• 描述: JNJ-49095397(RV-568)是一种特异性窄谱激酶抑制剂,可抑制一组参与COPD炎症的激酶,p38α,p38γ和HCK的IC50分别为5,40和52 nM；显示出有效的抗炎作用。在单核细胞和巨噬细胞中,证明了poly I:C刺激的BEAS-2B细胞和与皮质类固醇结合的香烟烟雾模型中的协同相互作用。COPD 2期临床
• 参考文献: References 1. Onions ST, et al. J Med Chem. 2016 Mar 10;59(5):1727-46. 2. Charron CE, et al. Eur Respir J. 2017 Oct 26;50(4). pii: 1700188. View Related Products by Target p38 MAPK COPD

JNJ-49095397物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 738.0±60.0 °C at 760 mmHg
• 分子式: C₃₄H₃₆N₆O₄
• 分子量: 592.687
• 闪点: 400.1±32.9 °C
• 精确质量: 592.279785
• LogP: 6.50
• InChIKey: RTDCVLCTBQDLBW-UHFFFAOYSA-N
• SMILES: COCC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c3ccccc23)ccn1
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.627

JNJ-49095397靶点实验

查看更多实验

实验名称：Antiinflammatory activity in differentiated human U937 cells assessed as inhibition o... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3783190

实验名称：Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 pr... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 14 External Id：CHEMBL3783189

实验名称：Antiinflammatory activity in differentiated human U937 cells assessed as inhibition o... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3783188

实验名称：Fluorescence Resonance Energy Transfer (FRET) Assay from US Patent US8933228: "Respir... 来源：BindingDB 靶标：N/A External Id：BindingDB_6638_1

实验名称：Antiinflammatory activity in Balb/c mouse assessed as inhibition of neutrophil accumu... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3783195

实验名称：Protein binding in plasma (unknown origin) 来源：ChEMBL 靶标：N/A External Id：CHEMBL3783299

实验名称：Antiinflammatory activity in tobaco smoke-induced A/J mouse steroid refractory inflam... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3783298

实验名称：Inhibition of human recombinant p38 gamma assessed as phosphorylation of MAPKAP-K2 pr... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 12 External Id：CHEMBL3783187

实验名称：Inhibition of HCK (unknown origin) preincubated for 2 hrs followed by FRET peptide ad... 来源：ChEMBL 靶标：Tyrosine-protein kinase HCK External Id：CHEMBL3783186

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JNJ-49095397英文别名

• Jnj-49095397
• 2-Methoxy-N-[4-({[4-({[1-(4-methylphenyl)-3-(2-methyl-2-propanyl)-1H-pyrazol-5-yl]carbamoyl}amino)-1-naphthyl]oxy}methyl)-2-pyridinyl]acetamide