JNJ-49095397
Modify Date: 2025-08-28 11:31:33
JNJ-49095397 structure
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Common Name | JNJ-49095397 | ||
|---|---|---|---|---|
| CAS Number | 1220626-82-3 | Molecular Weight | 592.687 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 738.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C34H36N6O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 400.1±32.9 °C | |
Use of JNJ-49095397JNJ-49095397 (RV-568) is a specific narrow-spectrum kinase inhibitor that inhibits a selected set of kinases involved in COPD inflammation with IC50 of 5, 40 and 52 nM for p38α, p38γ and HCK, respectively; shows potent anti-inflammatory effects in monocytes and macrophages, demonstrates synergistic interaction in poly I:C-stimulated BEAS-2B cells and in the cigarette smoke model combined with corticosteroid. COPD Phase 2 Clinical |
| Name | Jnj-49095397 |
|---|---|
| Synonym | More Synonyms |
| Description | JNJ-49095397 (RV-568) is a specific narrow-spectrum kinase inhibitor that inhibits a selected set of kinases involved in COPD inflammation with IC50 of 5, 40 and 52 nM for p38α, p38γ and HCK, respectively; shows potent anti-inflammatory effects in monocytes and macrophages, demonstrates synergistic interaction in poly I:C-stimulated BEAS-2B cells and in the cigarette smoke model combined with corticosteroid. COPD Phase 2 Clinical |
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| References | References 1. Onions ST, et al. J Med Chem. 2016 Mar 10;59(5):1727-46. 2. Charron CE, et al. Eur Respir J. 2017 Oct 26;50(4). pii: 1700188. View Related Products by Target p38 MAPK COPD |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 738.0±60.0 °C at 760 mmHg |
| Molecular Formula | C34H36N6O4 |
| Molecular Weight | 592.687 |
| Flash Point | 400.1±32.9 °C |
| Exact Mass | 592.279785 |
| LogP | 6.50 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.627 |
| Jnj-49095397 |
| Acetamide, N-[4-[[[4-[[[[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-1-naphthalenyl]oxy]methyl]-2-pyridinyl]-2-methoxy- |
| 2-Methoxy-N-[4-({[4-({[1-(4-methylphenyl)-3-(2-methyl-2-propanyl)-1H-pyrazol-5-yl]carbamoyl}amino)-1-naphthyl]oxy}methyl)-2-pyridinyl]acetamide |