CC214-2

• 常用名: CC214-2
• 英文名: CC214-2
• CAS号: 1228012-18-7
• 分子量: 383.44
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₅N₅O₃
• 熔点: N/A
• 闪点: N/A

CC214-2用途

CC214-2是一种有效的mTORC1/mTORC2双重抑制剂。结核分枝杆菌调节哺乳动物雷帕霉素(mTOR)信号靶点以阻止自噬。CC214-2有可能缩短结核病的持续时间[1]。

CC214-2名称

• 英文名: CC214-2

CC214-2生物活性

• 描述: CC214-2是一种有效的mTORC1/mTORC2双重抑制剂。结核分枝杆菌调节哺乳动物雷帕霉素(mTOR)信号靶点以阻止自噬。CC214-2有可能缩短结核病的持续时间[1]。
• 相关类别:
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> mTOR
  研究领域 >> 癌症
• 参考文献:

  [1]. Tasneen R, et al. Dual mTORC1/mTORC2 Inhibition as a Host-Directed Therapeutic Target in Pathologically Distinct Mouse Models of Tuberculosis. Antimicrob Agents Chemother. 2021;65(7):e0025321.

CC214-2物理化学性质

• 分子式: C₂₀H₂₅N₅O₃
• 分子量: 383.44
• InChIKey: UWUPKVZQISLSSA-UHFFFAOYSA-N
• SMILES: CC(C)(O)c1ccc(-c2cnc3c(n2)N(CC2CCOCC2)CC(=O)N3)cn1

CC214-2靶点实验

查看更多实验

实验名称：Inhibition of mTOR (unknown origin) assessed as remaining activity at 1 uM relative t... 来源：ChEMBL 靶标：Serine/threonine-protein kinase mTOR External Id：CHEMBL2352810

实验名称：Inhibition of p38alpha (unknown origin) assessed as remaining activity at 1 uM relati... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 14 External Id：CHEMBL2352809

实验名称：Inhibition of p38beta (unknown origin) assessed as remaining activity at 1 uM relativ... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 11 External Id：CHEMBL2352808

实验名称：Inhibition of p38delta (unknown origin) assessed as remaining activity at 1 uM relati... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 13 External Id：CHEMBL2352807

实验名称：Inhibition of cKit T670I mutant (unknown origin) assessed as remaining activity at 1 ... 来源：ChEMBL 靶标：Mast/stem cell growth factor receptor Kit External Id：CHEMBL2352814

实验名称：Inhibition of cSRC (unknown origin) assessed as remaining activity at 1 uM relative t... 来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase Src External Id：CHEMBL2352813

实验名称：Inhibition of IRRK2 G2019S mutant (unknown origin) assessed as remaining activity at ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2352812

实验名称：Inhibition of cSRC N1 mutant (unknown origin) assessed as remaining activity at 1 uM ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2352811

实验名称：Inhibition of p38gamma (unknown origin) assessed as remaining activity at 1 uM relati... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 12 External Id：CHEMBL2352806

实验名称：Inhibition of p70S6K (unknown origin) assessed as remaining activity at 1 uM relative... 来源：ChEMBL 靶标：Ribosomal protein S6 kinase beta-1 External Id：CHEMBL2352805

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