PF-05150122

• 常用名: PF-05150122
• 英文名: PF-05150122
• CAS号: 1235406-03-7
• 分子量: 531.885
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₀ClF₄N₅O₃S₂
• 熔点: N/A
• 闪点: N/A

PF-05150122用途

PF-05150122是一种有效的,状态依赖性的亚型选择性Nav1.7抑制剂,IC50为21 nM,对Nav1.5没有显着活性。疼痛阶段1已停止

PF-05150122名称

• 英文名: PF-05150122

PF-05150122生物活性

• 描述: PF-05150122是一种有效的,状态依赖性的亚型选择性Nav1.7抑制剂,IC50为21 nM,对Nav1.5没有显着活性。疼痛阶段1已停止
• 参考文献: References 1. Swain NA, et al. J Med Chem. 2017 Aug 24;60(16):7029-7042. 2. Jones HM, et al. Clin Pharmacokinet. 2016 Jul;55(7):875-87. View Related Products by Target Sodium Channel Pain

PF-05150122物理化学性质

• 分子式: C₁₉H₁₀ClF₄N₅O₃S₂
• 分子量: 531.885
• InChIKey: ZAGGUCLXSCVDCK-UHFFFAOYSA-N
• SMILES: O=S(=O)(Nc1nncs1)c1cc(Cl)c(Oc2ccc(C(F)(F)F)cc2-c2ccnnc2)cc1F

PF-05150122靶点实验

查看更多实验

实验名称：Plasma clearance in rat at 1 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4040120

实验名称：Plasma clearance in dog at 0.1 mg/kg, iv 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL4040121

实验名称：Volume of distribution at steady state in rat at 1 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4040119

实验名称：Inhibition of human NaV1.8 expressed in HEK cells assessed as half inactivation poten... 来源：ChEMBL 靶标：Sodium channel protein type 10 subunit alpha External Id：CHEMBL4040130

实验名称：Inhibition of rat NaV1.7 expressed in HEK cells assessed as half inactivation potenti... 来源：ChEMBL 靶标：Sodium channel protein type 9 subunit alpha External Id：CHEMBL4040131

实验名称：Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation poten... 来源：ChEMBL 靶标：Sodium channel protein type 3 subunit alpha External Id：CHEMBL4040128

实验名称：Inhibition of human NaV1.6 expressed in HEK cells assessed as half inactivation poten... 来源：ChEMBL 靶标：Sodium channel protein type 8 subunit alpha External Id：CHEMBL4040129

实验名称：Inhibition of human NaV1.1 expressed in HEK cells assessed as half inactivation poten... 来源：ChEMBL 靶标：Sodium channel protein type 1 subunit alpha External Id：CHEMBL4040126

实验名称：Inhibition of human NaV1.2 expressed in HEK cells assessed as half inactivation poten... 来源：ChEMBL 靶标：Sodium channel protein type 2 subunit alpha External Id：CHEMBL4040127

实验名称：Inhibition of human NaV1.5 expressed in HEK cells assessed as half inactivation poten... 来源：ChEMBL 靶标：Sodium channel protein type 5 subunit alpha External Id：CHEMBL4040124

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