N-[3-氯-4-[[(2-氯苯基)氨基]磺酰基]苯基]-2-吡啶甲酰胺

• 常用名: N-[3-氯-4-[[(2-氯苯基)氨基]磺酰基]苯基]-2-吡啶甲酰胺
• 英文名: VU 0364439
• CAS号: 1246086-78-1
• 分子量: 422.285
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₈H₁₃Cl₂N₃O₃S
• 熔点: N/A
• 闪点: N/A

用途

VU 0364439是mGlu4阳性变构调节剂(PAM),EC50为19.8 nM。

名称

• 中文名: N-[3-氯-4-[[(2-氯苯基)氨基]磺酰基]苯基]-2-吡啶甲酰胺
• 英文名: N-[3-chloro-4-[(2-chlorophenyl)sulfamoyl]phenyl]pyridine-2-carboxamide

生物活性

• 描述: VU 0364439是mGlu4阳性变构调节剂(PAM),EC50为19.8 nM。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Hong, Sang-Phyo; Liu, Kevin G.; Ma, Gil et al. Tricyclic Thiazolopyrazole Derivatives as Metabotropic Glutamate Receptor 4 Positive Allosteric Modulators. Journal of Medicinal Chemistry (2011), 54(14), 5070-5081.

  [2]. Engers, Darren W.; Gentry, Patrick R.; Williams, Richard et al. Synthesis and SAR of novel 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). Bioorganic & Medicinal Chem

  [3]. AJ Robichaud et al. Recent Progress on the Identification of Metabotropic Glutamate 4 Receptor Ligands and Their Potential Utility as CNS Therapeutics. ACS Chem. Neurosci. 2011, 2(8), 433-449.

物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₁₈H₁₃Cl₂N₃O₃S
• 分子量: 422.285
• 精确质量: 421.005463
• PSA: 100.03000
• LogP: 3.82
• 折射率: 1.686
• 储存条件: -20°C

英文别名

• cc-720
• CS-1000
• 2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-
• N-{3-Chloro-4-[(2-chlorophenyl)sulfamoyl]phenyl}-2-pyridinecarboxamide
• 2-Pyridinecarboxamide (N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]
• VU0364439
• VU 0364439