VU 0364439

Modify Date: 2024-01-02 18:05:42

VU 0364439 structure	Common Name	VU 0364439
	CAS Number	1246086-78-1	Molecular Weight	422.285
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₃Cl₂N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of VU 0364439

VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.IC50 Value: 19.8 nM(EC50)Target: mGluRin vitro:in vivo: VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).

Name	N-[3-chloro-4-[(2-chlorophenyl)sulfamoyl]phenyl]pyridine-2-carboxamide
Synonym	More Synonyms

Description	VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.IC50 Value: 19.8 nM(EC50)Target: mGluRin vitro:in vivo: VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Hong, Sang-Phyo; Liu, Kevin G.; Ma, Gil et al. Tricyclic Thiazolopyrazole Derivatives as Metabotropic Glutamate Receptor 4 Positive Allosteric Modulators. Journal of Medicinal Chemistry (2011), 54(14), 5070-5081. [2]. Engers, Darren W.; Gentry, Patrick R.; Williams, Richard et al. Synthesis and SAR of novel 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). Bioorganic & Medicinal Chem [3]. AJ Robichaud et al. Recent Progress on the Identification of Metabotropic Glutamate 4 Receptor Ligands and Their Potential Utility as CNS Therapeutics. ACS Chem. Neurosci. 2011, 2(8), 433-449.

Description

Related Catalog

Research Areas >> Neurological Disease

References

[1]. Hong, Sang-Phyo; Liu, Kevin G.; Ma, Gil et al. Tricyclic Thiazolopyrazole Derivatives as Metabotropic Glutamate Receptor 4 Positive Allosteric Modulators. Journal of Medicinal Chemistry (2011), 54(14), 5070-5081.

[2]. Engers, Darren W.; Gentry, Patrick R.; Williams, Richard et al. Synthesis and SAR of novel 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). Bioorganic & Medicinal Chem

[3]. AJ Robichaud et al. Recent Progress on the Identification of Metabotropic Glutamate 4 Receptor Ligands and Their Potential Utility as CNS Therapeutics. ACS Chem. Neurosci. 2011, 2(8), 433-449.

Density	1.5±0.1 g/cm3
Molecular Formula	C₁₈H₁₃Cl₂N₃O₃S
Molecular Weight	422.285
Exact Mass	421.005463
PSA	100.03000
LogP	3.82
Index of Refraction	1.686
Storage condition	-20°C

cc-720

CS-1000

2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-

N-{3-Chloro-4-[(2-chlorophenyl)sulfamoyl]phenyl}-2-pyridinecarboxamide

2-Pyridinecarboxamide (N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]

VU0364439

VU 0364439

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: VU0364439
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: VU0364439
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: VU0364439
Price: $400.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: VU0364439
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: $145/10mM*1mLinDMSO

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