JNJ-46356479

• 常用名: JNJ-46356479
• 英文名: JNJ-46356479
• CAS号: 1254979-66-2
• 分子量: 451.44
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₂F₅N₅
• 熔点: N/A
• 闪点: N/A

JNJ-46356479用途

JNJ-46356479是一种选择性和口服生物利用的mGlu2受体阳性变构调节剂(PAM)。JNJ-46356479显示mGlu2-PAM EC50＝78nM；mGlu2-PAM-Emax(%)=256。

JNJ-46356479名称

• 英文名: JNJ-46356479

JNJ-46356479生物活性

• 描述: JNJ-46356479是一种选择性和口服生物利用的mGlu2受体阳性变构调节剂(PAM)。JNJ-46356479显示mGlu2-PAM EC50＝78nM；mGlu2-PAM-Emax(%)=256。
• 参考文献: 1. Cid JM, Tresadern G, Vega JA, de Lucas AI, Del Cerro A, Matesanz E, Linares ML, García A, Iturrino L, Pérez-Benito L, Macdonald GJ, Oehlrich D, Lavreysen H, Peeters L, Ceusters M, Ahnaou A, Drinkenburg W, Mackie C, Somers M, Trabanco AA. Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). J Med Chem. 2016 Aug 31. [Epub ahead of print] PubMed PMID: 27579727.

JNJ-46356479物理化学性质

• 分子式: C₂₂H₂₂F₅N₅
• 分子量: 451.44
• InChIKey: BNJUYVSEWGRELC-UHFFFAOYSA-N
• SMILES: Fc1ccc(N2CCN(Cc3ccn4c(CC5CC5)nnc4c3C(F)(F)F)CC2)c(F)c1

JNJ-46356479靶点实验

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实验名称：AUC (0 to infinity) in Beagle dog at 1 mg/kg, iv or 5 mg/kg, po 来源：ChEMBL 靶标：N/A External Id：CHEMBL3858875

实验名称：Oral bioavailability in Beagle dog at 5 mg/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL3858877

实验名称：Ratio of drug level in brain to plasma of Swiss mouse at 10 mg/kg, sc measured after ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3858871

实验名称：Clearance in Beagle dog at 1 mg/kg, iv or 5 mg/kg, po 来源：ChEMBL 靶标：N/A External Id：CHEMBL3858872

实验名称：Half life in Beagle dog at 1 mg/kg, iv or 5 mg/kg, po 来源：ChEMBL 靶标：N/A External Id：CHEMBL3858873

实验名称：Tmax in Beagle dog at 1 mg/kg, iv or 5 mg/kg, po 来源：ChEMBL 靶标：N/A External Id：CHEMBL3858874

实验名称：Genotoxicity in Salmonella typhimurium 来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Typhimurium External Id：CHEMBL3858885

实验名称：Positive allosteric modulation at human mGlu3 receptor 来源：ChEMBL 靶标：Metabotropic glutamate receptor 3 External Id：CHEMBL3858886

实验名称：Dissociation constant, pKa of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL3858859

实验名称：Solubility of the compound in water at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL3858860

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