JNJ-46356479
Modify Date: 2024-10-06 18:32:33
JNJ-46356479 structure
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Common Name | JNJ-46356479 | ||
|---|---|---|---|---|
| CAS Number | 1254979-66-2 | Molecular Weight | 451.44 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H22F5N5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JNJ-46356479JNJ-46356479 is a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). JNJ-46356479 showed mGlu2 PAM EC50=78 nM; mGlu2 PAM Emax (%) = 256. |
| Name | JNJ-46356479 |
|---|
| Description | JNJ-46356479 is a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). JNJ-46356479 showed mGlu2 PAM EC50=78 nM; mGlu2 PAM Emax (%) = 256. |
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| References | 1. Cid JM, Tresadern G, Vega JA, de Lucas AI, Del Cerro A, Matesanz E, Linares ML, García A, Iturrino L, Pérez-Benito L, Macdonald GJ, Oehlrich D, Lavreysen H, Peeters L, Ceusters M, Ahnaou A, Drinkenburg W, Mackie C, Somers M, Trabanco AA. Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). J Med Chem. 2016 Aug 31. [Epub ahead of print] PubMed PMID: 27579727. |
| Molecular Formula | C22H22F5N5 |
|---|---|
| Molecular Weight | 451.44 |