2-氨基-1,1,3-三氰基-4-(3',4',5'-三羟基苯基)丁二烯

更新时间：2024-01-13 18:07:49

2-氨基-1,1,3-三氰基-4-(3',4',5'-三羟基苯基)丁二烯结构式	常用名	2-氨基-1,1,3-三氰基-4-(3',4',5'-三羟基苯基)丁二烯	英文名	Tyrphostin 51
	CAS号	126433-07-6	分子量	268.228
	密度	1.6±0.1 g/cm3	沸点	788.2±60.0 °C at 760 mmHg
	分子式	C₁₃H₈N₄O₃	熔点	N/A
	MSDS	美版	闪点	430.5±32.9 °C

用途

酪氨酸磷蛋白A51是一种有效的蛋白酪氨酸激酶(PTK)抑制剂。酪磷素A51以剂量依赖性方式抑制[3H]牛磺酸的体积依赖性释放。酪磷蛋白A51显著降低细胞酪氨酸磷酸化水平。酪磷蛋白A51抑制基础和EGF诱导的人骨细胞增殖[1][2]。

中文名	2-氨基-1,1,3-三氰基-4-(3',4',5'-三羟基苯基)丁二烯
英文名	(3Z)-2-Amino-4-(3,4,5-trihydroxyphenyl)-1,3-butadiene-1,1,3-tricarbonitrile
英文别名	更多

描述	酪氨酸磷蛋白A51是一种有效的蛋白酪氨酸激酶(PTK)抑制剂。酪磷素A51以剂量依赖性方式抑制[3H]牛磺酸的体积依赖性释放。酪磷蛋白A51显著降低细胞酪氨酸磷酸化水平。酪磷蛋白A51抑制基础和EGF诱导的人骨细胞增殖[1][2]。
相关类别	信号通路 >> JAK/STAT信号通路 >> EGFR 研究领域 >> 其他信号通路 >> 蛋白酪氨酸激酶 >> EGFR
参考文献	[1]. Alexander A. et al. [3H]taurine andd-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases. Physiology-cell physiology. 1999, 1226-1230. [2]. Yoon HK, et al. Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation. Calcif Tissue Int. 1998 Sep;63(3):243-9.

描述

相关类别

信号通路 >> JAK/STAT信号通路 >> EGFR

研究领域 >> 其他

信号通路 >> 蛋白酪氨酸激酶 >> EGFR

参考文献

[1]. Alexander A. et al. [3H]taurine andd-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases. Physiology-cell physiology. 1999, 1226-1230.

[2]. Yoon HK, et al. Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation. Calcif Tissue Int. 1998 Sep;63(3):243-9.

密度	1.6±0.1 g/cm3
沸点	788.2±60.0 °C at 760 mmHg
分子式	C₁₃H₈N₄O₃
分子量	268.228
闪点	430.5±32.9 °C
精确质量	268.059631
LogP	0.04
外观性状	固体
蒸汽压	0.0±2.8 mmHg at 25°C
折射率	1.757
储存条件	2-8°C

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.

J. Med. Chem. 32 , 2344, (1989)

A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic series of molecules with a progressive increase in affinity toward the su...

Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors.

Science 242(4880) , 933-5, (1988)

A systematic series of low molecular weight protein tyrosine kinase inhibitors were synthesized; they had progressively increasing affinity over a 2500-fold range toward the substrate site of epiderma...

Epidermal growth factor receptor inhibition by tyrphostin 51 induces apoptosis in luteinized granulosa cells.

J. Clin. Endocrinol. Metab. 90(1) , 469-73, (2005)

Growth factors may be involved in the control of ovarian cell fate and could contribute to regulation of ovarian cell apoptosis. Our objective is to test the hypothesis that, in human luteinized granu...

MFCD00133903

1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (3Z)-

1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (Z)-

(3Z)-2-Amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile

(3Z)-2-Amino-4-(3,4,5-trihydroxyphenyl)-1,3-butadiene-1,1,3-tricarbonitrile