S6K-18

• 常用名: S6K-18
• 英文名: S6K-18
• CAS号: 1265789-88-5
• 分子量: 358.41
• 密度: 1.5±0.1 g/cm3
• 沸点: 494.9±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₈N₄O₃S
• 熔点: N/A
• 闪点: 253.1±28.7 °C

S6K-18用途

S6K-18是一种有效的选择性p70S6K1抑制剂,IC50为52 nM【1】。

S6K-18名称

• 英文名: 2-(3-(1H-indazol-5-yl)ureido)-5-tert-butylthiophene-3-carboxylic acid

S6K-18生物活性

• 描述: S6K-18是一种有效的选择性p70S6K1抑制剂,IC50为52 nM【1】。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> MAPK/ERK信号通路 >> 核糖体S6激酶(RSK)
• 靶点实验:

  S6K1:52 nM (IC50)

• 参考文献:

  [1]. Ye P, et al. Potent and selective thiophene urea-templated inhibitors of S6K. Bioorg Med Chem Lett. 2011 Jan 15;21(2):849-52.

S6K-18物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 494.9±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₈N₄O₃S
• 分子量: 358.41
• 闪点: 253.1±28.7 °C
• 精确质量: 358.109955
• PSA: 135.35000
• LogP: 5.22
• InChIKey: BSRFCMMJUFQEOX-UHFFFAOYSA-N
• SMILES: CC(C)(C)c1cc(C(=O)O)c(NC(=O)Nc2ccc3[nH]ncc3c2)s1
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.746
• 储存条件: -20°C， 充氩

S6K-18靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Kinetic solubility of the compound in 50 mM phosphate buffer at pH 6.5 来源：ChEMBL 靶标：N/A External Id：CHEMBL1646056

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Permeability of the compound by PAMPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL1646057

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Half life in human liver microsomes at 1 uM by LC/MS/MS analysis 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1646058

实验名称：Inhibition of CYP1A2 at 3 uM by LC/MS/MS analysis 来源：ChEMBL 靶标：Cytochrome P450 1A2 External Id：CHEMBL1646060

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

实验名称：Inhibition of CYP2C9 at 3 uM by LC/MS/MS analysis 来源：ChEMBL 靶标：Cytochrome P450 2C9 External Id：CHEMBL1646061

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_L363-m4-1

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S6K-18英文别名

• 2-[(1H-Indazol-5-ylcarbamoyl)amino]-5-(2-methyl-2-propanyl)-3-thiophenecarboxylic acid
• S6K-18