S6K-18

Modify Date: 2024-01-12 08:48:02

S6K-18 Structure
S6K-18 structure
Common Name S6K-18
CAS Number 1265789-88-5 Molecular Weight 358.41
Density 1.5±0.1 g/cm3 Boiling Point 494.9±45.0 °C at 760 mmHg
Molecular Formula C17H18N4O3S Melting Point N/A
MSDS N/A Flash Point 253.1±28.7 °C

 Use of S6K-18


S6K-18 is a potent and selective p70S6K1 inhibitor with an IC50 of 52 nM[1].

 Names

Name 2-(3-(1H-indazol-5-yl)ureido)-5-tert-butylthiophene-3-carboxylic acid
Synonym More Synonyms

 S6K-18 Biological Activity

Description S6K-18 is a potent and selective p70S6K1 inhibitor with an IC50 of 52 nM[1].
Related Catalog
Target

S6K1:52 nM (IC50)

References

[1]. Ye P, et al. Potent and selective thiophene urea-templated inhibitors of S6K. Bioorg Med Chem Lett. 2011 Jan 15;21(2):849-52.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 494.9±45.0 °C at 760 mmHg
Molecular Formula C17H18N4O3S
Molecular Weight 358.41
Flash Point 253.1±28.7 °C
Exact Mass 358.109955
PSA 135.35000
LogP 5.22
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.746

 Synonyms

2-[(1H-Indazol-5-ylcarbamoyl)amino]-5-(2-methyl-2-propanyl)-3-thiophenecarboxylic acid
3-Thiophenecarboxylic acid, 5-(1,1-dimethylethyl)-2-[[(1H-indazol-5-ylamino)carbonyl]amino]-
S6K-18