N-((3s,4r)-6-氰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基)-n-羟基乙酰胺

• 常用名: N-((3s,4r)-6-氰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基)-n-羟基乙酰胺
• 英文名: Y-26763
• CAS号: 127408-31-5
• 分子量: 276.29
• 密度: 1.36g/cm3
• 沸点: 455.4ºC at 760mmHg
• 分子式: C₁₄H₁₆N₂O₄
• 熔点: N/A
• 闪点: 229.2ºC

用途

Y-26763 是 K+ 通道开放剂。Y-26763 是 Y-27152 的活性代谢物。Y-26763 是 ATP 敏感的 K+ (KATP) 通道激活剂。

名称

• 中文名: N-((3s,4r)-6-氰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基)-n-羟基乙酰胺
• 英文名: N-[(3S,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-hydroxyacetamide

生物活性

• 描述: Y-26763 是 K+ 通道开放剂。Y-26763 是 Y-27152 的活性代谢物。Y-26763 是 ATP 敏感的 K+ (KATP) 通道激活剂。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 跨膜转运 >> 钾通道
• 参考文献:

  [1]. Itoh T, et al. Effects of a newly synthesized K+ channel opener, Y-26763, on noradrenaline-induced Ca2+ mobilization in smooth muscle of the rabbit mesenteric artery. Br J Pharmacol. 1994 Jan;111(1):165-72.

  [2]. Tran QTN, et al. The identification of naturally occurring labdane diterpenoid calcaratarin D as a potential anti-inflammatory agent. Eur J Med Chem. 2019 Jul 15;174:33-44.

物理化学性质

• 密度: 1.36g/cm3
• 沸点: 455.4ºC at 760mmHg
• 分子式: C₁₄H₁₆N₂O₄
• 分子量: 276.29
• 闪点: 229.2ºC
• 精确质量: 276.11100
• PSA: 93.79000
• LogP: 1.36898
• InChIKey: IWTCFIIOUXJOOV-OLZOCXBDSA-N
• SMILES: CC(=O)N(O)C1c2cc(C#N)ccc2OC(C)(C)C1O
• 蒸汽压: 4.4E-09mmHg at 25°C
• 折射率: 1.615
• 储存条件: 2-8℃

靶点实验

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英文别名

• hms3268j05