cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine

• 常用名: cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
• 英文名: cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
• CAS号: 127757-45-3
• 分子量: 261.17200
• 密度: 1.83g/cm3
• 沸点: 495.6ºC at 760mmHg
• 分子式: C₈H₁₂N₃O₅P
• 熔点: N/A
• 闪点: 253.5ºC

用途

环HPMPC是一种有效的抗病毒药物。周期性HPMPC可以提高致命痘苗病毒(IHD株)感染小鼠的动脉血氧饱和度水平。在豚鼠模型中,周期性HPMPC可改善先天性豚鼠巨细胞病毒(GPCMV)感染的转归,并减少病毒复制[1][2]。

名称

• 英文名: 4-amino-1-[[(5S)-2-hydroxy-2-oxo-1,4,2λ5-dioxaphosphinan-5-yl]methyl]pyrimidin-2-one

生物活性

• 描述: 环HPMPC是一种有效的抗病毒药物。周期性HPMPC可以提高致命痘苗病毒(IHD株)感染小鼠的动脉血氧饱和度水平。在豚鼠模型中,周期性HPMPC可改善先天性豚鼠巨细胞病毒(GPCMV)感染的转归,并减少病毒复制[1][2]。
• 相关类别:
  信号通路 >> 抗感染 >> CMV
• 靶点实验:

  Vaccinia virus, GPCMV[1]

物理化学性质

• 密度: 1.83g/cm3
• 沸点: 495.6ºC at 760mmHg
• 分子式: C₈H₁₂N₃O₅P
• 分子量: 261.17200
• 闪点: 253.5ºC
• 精确质量: 261.05100
• PSA: 127.47000
• InChIKey: YXQUGSXUDFTPLL-LURJTMIESA-N
• SMILES: Nc1ccn(CC2COP(=O)(O)CO2)c(=O)n1
• 蒸汽压: 3.57E-11mmHg at 25°C
• 折射率: 1.709

靶点实验

查看更多实验

实验名称：Antiviral activity against Punta Toro virus in Vero cells reduction of virus-induced ... 来源：ChEMBL 靶标：Punta Toro virus External Id：CHEMBL900343

实验名称：Cytotoxicity against HeLa cells assessed as alteration in morphology after 3 days 来源：ChEMBL 靶标：HeLa External Id：CHEMBL900315

实验名称：Cytotoxicity against Vero cells assessed as alteration in morphology after 3 days 来源：ChEMBL 靶标：Vero External Id：CHEMBL900344

实验名称：Cytotoxicity against C3H cells assessed as alteration in morphology after 3 days 来源：ChEMBL 靶标：N/A External Id：CHEMBL900345

实验名称：Antiviral activity against RSV in HeLa cells assessed as reduction of virus-induced c... 来源：ChEMBL 靶标：Respiratory syncytial virus External Id：CHEMBL900339

实验名称：Antiviral activity against Parainfluenza 3 in Vero cells reduction of virus-induced c... 来源：ChEMBL 靶标：Human respirovirus 3 External Id：CHEMBL900340

实验名称：Antiviral activity against Reovirus 1 in Vero cells reduction of virus-induced cytopa... 来源：ChEMBL 靶标：Mammalian orthoreovirus 1 External Id：CHEMBL900341

实验名称：Antiviral activity against Sindbis virus in Vero cells reduction of virus-induced cyt... 来源：ChEMBL 靶标：Sindbis virus External Id：CHEMBL900342

实验名称：Antiviral activity against Murine polyomavirus PTA in mouse UC1B cells assessed as re... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL921192

实验名称：Antiviral activity against HSV1 KOS infected in HFF cells incubated for 3 days by pla... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL1931883

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英文别名

• cyclic cidofovir
• cCDV
• cyclic HPMPC
• Chpmpc
• GS 930