cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine

Modify Date: 2024-01-20 17:36:33

cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine structure	Common Name	cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
	CAS Number	127757-45-3	Molecular Weight	261.17200
	Density	1.83g/cm3	Boiling Point	495.6ºC at 760mmHg
	Molecular Formula	C₈H₁₂N₃O₅P	Melting Point	N/A
	MSDS	N/A	Flash Point	253.5ºC

Use of cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine

Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model[1][2].

Name	4-amino-1-[[(5S)-2-hydroxy-2-oxo-1,4,2λ5-dioxaphosphinan-5-yl]methyl]pyrimidin-2-one
Synonym	More Synonyms

Description	Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> CMV
Target	Vaccinia virus, GPCMV[1]

Density	1.83g/cm3
Boiling Point	495.6ºC at 760mmHg
Molecular Formula	C₈H₁₂N₃O₅P
Molecular Weight	261.17200
Flash Point	253.5ºC
Exact Mass	261.05100
PSA	127.47000
Vapour Pressure	3.57E-11mmHg at 25°C
Index of Refraction	1.709

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cyclic-1-(3-hyd...

CAS#:127757-45-3

Literature: Beadle, James R.; Hartline, Caroll; Aldern, Kathy A.; Rodriguez, Natalie; Harden, Emma; Kern, Earl R.; Hostetler, Karl Y. Antimicrobial Agents and Chemotherapy, 2002 , vol. 46, # 8 p. 2381 - 2386