AS 2444697

• 常用名: AS 2444697
• 英文名: AS 2444697
• CAS号: 1287665-60-4
• 分子量: 432.861
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₁ClN₆O₄
• 熔点: N/A
• 闪点: N/A

AS 2444697用途

一种有效的,选择性的,口服生物可利用的IRAK-4抑制剂,以亚纳摩尔顺序有效抑制人和大鼠IRAK-4活性,对IRAK-1的选择性>30倍；抑制IL-1β或TLR配体脂多糖(LPS)诱导人肺泡上皮细胞,成纤维细胞样滑膜细胞中IL-6的产生,和外周血单核细胞；显着减少尿蛋白排泄,预防肾小球硬化和间质纤维化的发展,而不影响慢性肾病小鼠模型的血压。

AS 2444697名称

• 英文名: AS2444697

AS 2444697生物活性

• 描述: 一种有效的,选择性的,口服生物可利用的IRAK-4抑制剂,以亚纳摩尔顺序有效抑制人和大鼠IRAK-4活性,对IRAK-1的选择性>30倍；抑制IL-1β或TLR配体脂多糖(LPS)诱导人肺泡上皮细胞,成纤维细胞样滑膜细胞中IL-6的产生,和外周血单核细胞；显着减少尿蛋白排泄,预防肾小球硬化和间质纤维化的发展,而不影响慢性肾病小鼠模型的血压。
• 参考文献: References 1. Kondo M, et al. Naunyn Schmiedebergs Arch Pharmacol. 2014 Oct;387(10):909-19. 2. Imanishi J, et al. Arthritis Rheum 63:S390. View Related Products by Target IRAK

AS 2444697物理化学性质

• 分子式: C₁₉H₂₁ClN₆O₄
• 分子量: 432.861
• 精确质量: 432.131287
• InChIKey: FGNHLIIFEDYNFZ-UHFFFAOYSA-N
• SMILES: Cc1cc(-c2nc(C(=O)Nc3cn(C4CCOCC4)nc3C(N)=O)co2)ccn1.Cl
• 储存条件: 室温，干燥，密封

AS 2444697安全信息

• 危害码 (欧洲): Xi

AS 2444697靶点实验

查看更多实验

实验名称：Inhibition of human IRAK4 using biotinylated FGLARFSRFAGSSPSQSSMVARTQTVRGT peptide as... 来源：ChEMBL 靶标：Interleukin-1 receptor-associated kinase 4 External Id：CHEMBL5260512

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Tmax in Sprague-Dawley rat at 1 mg/kg, po administered as single dose measured upto 2... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5260546

实验名称：AUC(0 to infinity) in Sprague-Dawley rat at 1 mg/kg, po administered as single dose m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5260548

实验名称：Oral bioavailability in Sprague-Dawley rat at 1 mg/kg administered as single dose mea... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5260547

实验名称：Total clearance in Sprague-Dawley rat at 1 mg/kg, iv administered as single dose meas... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5260542

实验名称：AUC(0 to infinity) in Sprague-Dawley rat at 1 mg/kg, iv administered as single dose m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5260541

实验名称：Half life in Sprague-Dawley rat at 1 mg/kg, iv administered as single dose measured u... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5260544

实验名称：Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv administe... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5260543

实验名称：Inhibition of PDGFRalpha (unknown origin) at 1 uM relative to control 来源：ChEMBL 靶标：Platelet-derived growth factor receptor alpha External Id：CHEMBL5260538

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AS 2444697英文别名

• AS 2444697
• N-[3-Carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-1,3-oxazole-4-carboxamide hydrochloride (1:1)
• MFCD30182294
• 4-Oxazolecarboxamide, N-[3-(aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-, hydrochloride (1:1)
• N-[3-Carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide
• AS2444697
• N-[3-(Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl-2-(2-methyl-4-pyridinyl)-4-Oxazolecarboxamide hydrochloride (1:1)