(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) trifluoroacetate salt

• 常用名: (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) trifluoroacetate salt
• 英文名: (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) trifluoroacetate salt
• CAS号: 129622-68-0
• 分子量: 3478.06
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₆₂H₂₅₄N₅₀O₃₆
• 熔点: N/A
• 闪点: N/A

用途

(Asn10,Leu11,D-Trp12)-pTH相关蛋白(7-34)酰胺(人、小鼠、大鼠)是一种强效的pTH-1R拮抗剂[1][2]。

名称

• 英文名: (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) trifluoroacetate salt

生物活性

• 描述: (Asn10,Leu11,D-Trp12)-pTH相关蛋白(7-34)酰胺(人、小鼠、大鼠)是一种强效的pTH-1R拮抗剂[1][2]。
• 相关类别:
  研究领域 >> 代谢疾病
• 靶点实验:

  PTH1R

• 参考文献:

  [1]. Nutt RF, et al. Removal of partial agonism from parathyroid hormone (PTH)-related protein-(7-34)NH2 by substitution of PTH amino acids at positions 10 and 11. Endocrinology. 1990 Jul;127(1):491-3.

  [2]. Portal-Núñez S, et al. Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains. Bone Joint Res. 2018 Jan;7(1):58-68.

物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₁₆₂H₂₅₄N₅₀O₃₆
• 分子量: 3478.06
• 精确质量: 3475.958252
• LogP: 0.51
• 折射率: 1.664

英文别名

• L-Leucyl-L-leucyl-L-histidyl-L-asparaginyl-L-leucyl-D-tryptophyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-α-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-phenylalanyl-L-phenylalanyl-L-leucyl -L-histidyl-L-histidyl-L-leucyl-L-isoleucyl-L-alanyl-L-α-glutamyl-L-isoleucyl-L-histidyl-L-threonyl-L-alaninamide
• MFCD00214657