3,5二羟基胆甾-6-酮

• 常用名: 3,5二羟基胆甾-6-酮
• 英文名: 3β,5α-Dihydroxycholestan-6-one
• CAS号: 13027-33-3
• 分子量: 418.652
• 密度: 1.1±0.1 g/cm3
• 沸点: 528.9±45.0 °C at 760 mmHg
• 分子式: C₂₇H₄₆O₃
• 熔点: N/A
• 闪点: 287.7±25.2 °C

3,5二羟基胆甾-6-酮用途

5α-羟基-6-酮基胆固醇是完整培养的人支气管上皮细胞(16-HBE)直接暴露于臭氧中期间β-环氧化合物(5α,6β-环氧胆固醇)的主要代谢产物。5α-羟基-6-酮基胆固醇抑制胆固醇合成,IC50为350 nM[1]。

3,5二羟基胆甾-6-酮名称

• 中文名: 3,5二羟基胆甾-6-酮
• 英文名: 5alpha-cholestan-3beta,5alpha-diol-6-one

3,5二羟基胆甾-6-酮生物活性

• 描述: 5α-羟基-6-酮基胆固醇是完整培养的人支气管上皮细胞(16-HBE)直接暴露于臭氧中期间β-环氧化合物(5α,6β-环氧胆固醇)的主要代谢产物。5α-羟基-6-酮基胆固醇抑制胆固醇合成,IC50为350 nM[1]。
• 相关类别:
  研究领域 >> 心血管疾病
• 体外研究: 5α-羟基-6-酮基胆固醇(0.01,0.1,1,10μM)对培养的16-HBE细胞具有细胞毒性[1]。
• 参考文献:

  [1]. Melissa K Pulfer, et al. Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant. J Biol Chem. 2004 Jun 18;279(25):26331-8.

3,5二羟基胆甾-6-酮物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 528.9±45.0 °C at 760 mmHg
• 分子式: C₂₇H₄₆O₃
• 分子量: 418.652
• 闪点: 287.7±25.2 °C
• 精确质量: 418.344696
• PSA: 57.53000
• LogP: 7.00
• InChIKey: SJZZRXMQSAXCFD-ZCBMJONGSA-N
• SMILES: CC(C)CCCC(C)C1CCC2C3CC(=O)C4(O)CC(O)CCC4(C)C3CCC12C
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.531

3,5二羟基胆甾-6-酮靶点实验

查看更多实验

实验名称：Cytotoxicity against human HT-29 cells assessed as cell viability after 48 hrs by ala... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL1825446

实验名称：Cytotoxicity against human HT-29 cells after 48 hrs by Alamar blue assay 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL1286346

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Displacement of [3H]-25-OHC from human OSBP overexpressed in HEK293T cell lysate asse... 来源：ChEMBL 靶标：Oxysterol-binding protein 1 External Id：CHEMBL5320826

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Cytotoxicity against human ARPE19 cells assessed as cell viability after 48 hrs by al... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1825453

实验名称：Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in... 来源：ChEMBL 靶标：NPC1-like intracellular cholesterol transporter 1 External Id：CHEMBL3362445

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

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3,5二羟基胆甾-6-酮英文别名

• CHOLESTANE-6-OXO-3,5-DIOL
• (3β,5α)-3,5-Dihydroxycholestan-6-one
• CHOLESTANE-6-OXO-3BETA,5ALPHA-DIOL
• 5ALPHA-HYDROXY-6-KETO CHOLESTEROL
• YS-64
• yakkasterone
• 3β,5α-Dihydroxycholestan-6-one