MK2-IN-1

• 常用名: MK2-IN-1
• 英文名: MK2-IN-1
• CAS号: 1314118-92-7
• 分子量: 472.966
• 密度: 1.3±0.1 g/cm3
• 沸点: 699.2±55.0 °C at 760 mmHg
• 分子式: C₂₇H₂₅ClN₄O₂
• 熔点: N/A
• 闪点: 376.7±31.5 °C

MK2-IN-1用途

MK2-IN-1是MAPKAPK2(MK2)激酶高效选择性抑制剂,IC50值0.11uM。

MK2-IN-1名称

• 中文名: MK2-IN-1
• 英文名: MK2-IN-1

MK2-IN-1生物活性

• 描述: MK2-IN-1是MAPKAPK2(MK2)激酶高效选择性抑制剂,IC50值0.11uM。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> MAPKAPK2(MK2)
  研究领域 >> 癌症
• 参考文献:

  [1]. Rao AU, et al. Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1068-72.

  [2]. Huang X, et al. A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70.

  [3]. Huang X, et al. Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors. ACS Med Chem Lett. 2011 Jun 24;2(8):632-7.

MK2-IN-1物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 699.2±55.0 °C at 760 mmHg
• 分子式: C₂₇H₂₅ClN₄O₂
• 分子量: 472.966
• 闪点: 376.7±31.5 °C
• 精确质量: 472.166595
• LogP: 2.69
• InChIKey: LIPNXDIBECKOMJ-UHFFFAOYSA-N
• SMILES: O=C(c1ccc(-c2ccc(Cl)cc2)o1)N(Cc1ccccn1)c1ccc(N2CCNCC2)cc1
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.643
• 储存条件: 2-8℃

MK2-IN-1靶点实验

查看更多实验

实验名称：Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins pri... 来源：ChEMBL 靶标：MAP kinase-activated protein kinase 2 External Id：CHEMBL2040538

实验名称：Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser... 来源：ChEMBL 靶标：MAP kinase-activated protein kinase 2 External Id：CHEMBL2040539

实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301363

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301365

实验名称：Inhibition of human CK1gamma3 at 10 uM 来源：ChEMBL 靶标：Casein kinase I isoform gamma-3 External Id：CHEMBL2019919

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301366

实验名称：Inhibition of LPS-stimulated TNFalpha production in human THP1 cells by ELISA 来源：ChEMBL 靶标：THP-1 External Id：CHEMBL1943216

实验名称：Inhibition of human MK2 来源：ChEMBL 靶标：MAP kinase-activated protein kinase 2 External Id：CHEMBL1943215

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

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MK2-IN-1英文别名

• 5-(4-Chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-2-furamide