BRD 0476

• 常用名: BRD 0476
• 英文名: BRD 0476
• CAS号: 1314958-91-2
• 分子量: 674.769
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₅H₃₈N₄O₈S
• 熔点: N/A
• 闪点: N/A

BRD 0476用途

BRD 0476(ML187)是泛素特异性肽酶9X(USP9X)的选择性中度抑制剂,抑制胰腺β细胞凋亡,抑制IFN-γ诱导的JAK2和STAT1信号传导,促进β细胞存活；不具有激酶抑制活性,对JAK1,JAK2或JAK3活性没有影响,去泛素化酶泛素特异性肽酶9X(USP9X)是BRD0476的细胞内靶标。

BRD 0476名称

• 英文名: BRD 0476

BRD 0476生物活性

• 描述: BRD 0476(ML187)是泛素特异性肽酶9X(USP9X)的选择性中度抑制剂,抑制胰腺β细胞凋亡,抑制IFN-γ诱导的JAK2和STAT1信号传导,促进β细胞存活；不具有激酶抑制活性,对JAK1,JAK2或JAK3活性没有影响,去泛素化酶泛素特异性肽酶9X(USP9X)是BRD0476的细胞内靶标。
• 参考文献: References 1. Chou DH, et al. J Am Chem Soc. 2015 Jun 24;137(24):7929-34. 2. Faloon PW, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 3. Chou DH, et al. ACS Med Chem Lett. 2011 Sep 8;2(9):698-702. View Related Products by Target Deubiquitinase (DUB)

BRD 0476物理化学性质

• 分子式: C₃₅H₃₈N₄O₈S
• 分子量: 674.769
• InChIKey: YDFFDCBBGWXONN-MODXFSQWSA-N
• SMILES: CC1CN(C(C)CO)C(=O)c2cccc(NC(=O)Nc3cccc4ccccc34)c2OC1CN(C)S(=O)(=O)c1ccc2c(c1)OCCO2

BRD 0476靶点实验

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实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Trypanosoma brucei RNA editing ligase 1 External Id：TBREL1_INH_FRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify act... 来源：The Scripps Research Institute Molecular Screening Center 靶标：TTR [Homo sapiens] External Id：TTR_ACT_LUMI_1536_1X%ACT PRUN

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] External Id：PLCB3_INH_QFRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：ADAM10 [Homo sapiens] External Id：ADAM10_INH_QFRET_1536_1X%INH PRUN

实验名称：Inhibition of IFNgamma-induced JAK1/JAK2 signaling in rat INS-1E cells assessed as ST... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2353844

实验名称：Cytoprotective activity in rat INS-1E cells assessed as suppression of cytokine-induc... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2353848

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] External Id：ABHD4_INH_FP_1536_1X%INH PRUN

实验名称：Thermodynamic solubility in PBS at pH 7.4 after 24 hrs by UPLC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL2353847

实验名称：Inhibition of JAK1/JAK2 in rat INS-1E cells assessed as inhibition of IFNgamma-induce... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2353846

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