BRD 0476
Modify Date: 2024-04-11 10:13:07
BRD 0476 structure
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Common Name | BRD 0476 | ||
|---|---|---|---|---|
| CAS Number | 1314958-91-2 | Molecular Weight | 674.769 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C35H38N4O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BRD 0476BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X), inhibits pancreatic β-cell apoptosis that inhibits IFN-γ-induced JAK2 and STAT1 signaling to promote β-cell survival; does not has kinase inhibitory activity, and no effect no effect on JAK1, JAK2, or JAK3 activities, and the deubiquitinase ubiquitin-specific peptidase 9X (USP9X) is an intracellular target of BRD0476. |
| Name | BRD 0476 |
|---|
| Description | BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X), inhibits pancreatic β-cell apoptosis that inhibits IFN-γ-induced JAK2 and STAT1 signaling to promote β-cell survival; does not has kinase inhibitory activity, and no effect no effect on JAK1, JAK2, or JAK3 activities, and the deubiquitinase ubiquitin-specific peptidase 9X (USP9X) is an intracellular target of BRD0476. |
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| References | References 1. Chou DH, et al. J Am Chem Soc. 2015 Jun 24;137(24):7929-34. 2. Faloon PW, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 3. Chou DH, et al. ACS Med Chem Lett. 2011 Sep 8;2(9):698-702. View Related Products by Target Deubiquitinase (DUB) |
| Molecular Formula | C35H38N4O8S |
|---|---|
| Molecular Weight | 674.769 |