EMA401游离态

更新时间：2025-08-24 21:54:17

EMA401游离态结构式	常用名	EMA401游离态	英文名	EMA401
	CAS号	1316755-16-4	分子量	507.576
	密度	1.3±0.1 g/cm3	沸点	745.3±60.0 °C at 760 mmHg
	分子式	C₃₂H₂₉NO₅	熔点	N/A
	MSDS	N/A	闪点	404.5±32.9 °C

EMA401游离态用途

Olodanrigan (EMA401) 是一个高选择性的AT2R拮抗剂,能够抑制p38和p42/p44 MAPK激活引起的AngII/AT2R的增加,能够抑制DRG神经元兴奋过度。

中文名	奥洛立更
英文名	EMA401
英文别名	更多

描述	Olodanrigan (EMA401) 是一个高选择性的AT2R拮抗剂,能够抑制p38和p42/p44 MAPK激活引起的AngII/AT2R的增加,能够抑制DRG神经元兴奋过度。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体研究领域 >> 神经疾病
参考文献	[1]. Rice AS et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial.Lancet. 2014 May 10;383(9929):1637-47. [2]. Anand U et al. Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies. Mol Pain. 2015 Jun 26;11:38. [3]. Rice AS et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial.Lancet. 2014 May 10;383(9929):1637-47.

描述

Olodanrigan (EMA401) 是一个高选择性的AT2R拮抗剂,能够抑制p38和p42/p44 MAPK激活引起的AngII/AT2R的增加,能够抑制DRG神经元兴奋过度。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体

研究领域 >> 神经疾病

参考文献

[1]. Rice AS et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial.Lancet. 2014 May 10;383(9929):1637-47.

[2]. Anand U et al. Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies. Mol Pain. 2015 Jun 26;11:38.

[3]. Rice AS et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial.Lancet. 2014 May 10;383(9929):1637-47.

密度	1.3±0.1 g/cm3
沸点	745.3±60.0 °C at 760 mmHg
分子式	C₃₂H₂₉NO₅
分子量	507.576
闪点	404.5±32.9 °C
精确质量	507.204559
LogP	5.98
InChIKey	GHBCIXGRCZIPNQ-MHZLTWQESA-N
SMILES	COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2
蒸汽压	0.0±2.6 mmHg at 25°C
折射率	1.631
储存条件	-20°C，干燥密封

实验名称：Thermal Shift Assay. Domain start/stop: M626-G740
来源：ChEMBL
靶标：Peregrin
External Id：CHEMBL4650107

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298
来源：ChEMBL
靶标：Cyclin-dependent kinase 2
External Id：CHEMBL5062802

实验名称：Thermal Shift Assay. Domain: start/stop: E122-S403
来源：ChEMBL
靶标：Aurora kinase A
External Id：CHEMBL5068045

实验名称：Thermal Shift Assay. Domain: start/stop: M1-K294
来源：ChEMBL
靶标：Casein kinase I isoform delta
External Id：CHEMBL5064329

实验名称：Thermal Shift Assay. Domain: start/stop: S229-K512
来源：ChEMBL
靶标：Tyrosine-protein kinase ABL1
External Id：CHEMBL5060613

实验名称：Incucyte cell viability with HEK293T
来源：ChEMBL
靶标：HEK-293T
External Id：CHEMBL5058565

实验名称：Thermal Shift Assay. Domain: start/stop: M26-R383
来源：ChEMBL
靶标：Glycogen synthase kinase-3 beta
External Id：CHEMBL5065589

实验名称：Thermal Shift Assay. Domain: start/stop: S229-K512
来源：ChEMBL
靶标：Tyrosine-protein kinase ABL1
External Id：CHEMBL5060015

实验名称：GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce...
来源：ChEMBL
靶标：N-formyl peptide receptor 2
External Id：CHEMBL5209826

实验名称：GPCR beta-arrestin recruitment assay with target: GLP1R Assay Type: PRESTO-Tango Conc...
来源：ChEMBL
靶标：Glucagon-like peptide 1 receptor
External Id：CHEMBL5209829

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