N-(1,1-二甲基乙基)-4-(2-甲氧基苯基)-ALPHA-苯基-1-哌嗪丙酰胺

• 常用名: N-(1,1-二甲基乙基)-4-(2-甲氧基苯基)-ALPHA-苯基-1-哌嗪丙酰胺
• 英文名: Way100135
• CAS号: 133025-23-7
• 分子量: 468.46000
• 密度: 1.085g/cm3
• 沸点: 582.8ºC at 760mmHg
• 分子式: C₂₄H₃₅Cl₂N₃O₂
• 熔点: N/A
• 闪点: 306.3ºC

用途

Way 100135 is a serotonergic drug of the phenylpiperazine family which is used in scientific research. It acts as potent 5-HT1A receptor antagonist, and was originally believed to be highly selective, but further studies have demonstrated that it also acts as a partial agonist of the 5-HT1D receptor (pKi = 7.58; virtually the same affinity for 5-HT1A), and to a much lesser extent, of the 5-HT1B receptor (pKi = 5.82). These findings may have prompted the development of the related compound WAY-100,635, another purportedly selective and even more potent 5-HT1A antagonist, which was synthesized shortly thereafter.

名称

• 中文名: (S)-n-叔丁基-3-(4-(2-甲氧基苯基)-哌嗪-1-基)-2-苯丙酰胺双盐酸盐
• 英文名: N-tert-butyl-3-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylpropanamide
• 中文别名: N-(1,1-二甲基乙基)-4-(2-甲氧基苯基)-ALPHA-苯基-1-哌嗪丙酰胺

物理化学性质

• 密度: 1.085g/cm3
• 沸点: 582.8ºC at 760mmHg
• 分子式: C₂₄H₃₅Cl₂N₃O₂
• 分子量: 468.46000
• 闪点: 306.3ºC
• 精确质量: 467.21100
• PSA: 44.81000
• LogP: 5.51350
• 蒸汽压: 1.43E-13mmHg at 25°C
• 折射率: 1.556