PF 1022A

• 常用名: PF 1022A
• 英文名: PF 1022A
• CAS号: 133413-70-4
• 分子量: 949.17900
• 密度: N/A
• 沸点: N/A
• 分子式: C₅₂H₇₆N₄O₁₂
• 熔点: N/A
• 闪点: N/A

PF 1022A用途

PF 1022A具有强抗寄生虫活性,作用方式是作为离子孔道。

PF 1022A名称

• 中文名: PF 1022A
• 英文名: Cyclo[(αR)​-​α-​hydroxybenzenepropan​oyl-​N-​methyl-​L-​leucyl-​(2R)​-​2-​hydroxypropanoyl-​N-​methyl-​L-​leucyl-​(αR)​-​α-​hydroxybenzenepropan​oyl-​N-​methyl-​L-​leucyl-​(2R)​-​2-​hydroxypropanoyl-​N-​methyl-​L-​leucyl]

PF 1022A生物活性

• 描述: PF 1022A具有强抗寄生虫活性,作用方式是作为离子孔道。
• 相关类别:
  信号通路 >> 抗感染 >> 寄生物
  研究领域 >> 感染
• 参考文献:

  [1]. Sasaki T, et al. A new anthelmintic cyclodepsipeptide, PF1022A. J Antibiot (Tokyo). 1992 May;45(5):692-7.

  [2]. Dornetshuber R, et al. Effects of the anthelmintic drug PF1022A on mammalian tissue and cells. Biochem Pharmacol. 2009 Apr 15;77(8):1437-44.

  [3]. Nwosu U, et al. Efficacy of the cyclooctadepsipeptide PF1022A against Heligmosomoides bakeri in vitro and in vivo. Parasitology. 2011 Aug;138(9):1193-201.

PF 1022A物理化学性质

• 分子式: C₅₂H₇₆N₄O₁₂
• 分子量: 949.17900
• 精确质量: 948.54600
• PSA: 186.44000
• LogP: 5.41640
• InChIKey: YJNUXGPXJFAUQJ-LYWANRAQSA-N
• SMILES: CC(C)CC1C(=O)OC(Cc2ccccc2)C(=O)N(C)C(CC(C)C)C(=O)OC(C)C(=O)N(C)C(CC(C)C)C(=O)OC(Cc2ccccc2)C(=O)N(C)C(CC(C)C)C(=O)OC(C)C(=O)N1C
• 储存条件: 2-8℃

PF 1022A靶点实验

查看更多实验

实验名称：Percent reduction of Haemonchus contortus in immunosuppressed jird (Meriones unguicul... 来源：ChEMBL 靶标：Meriones unguiculatus External Id：CHEMBL705796

实验名称：Anthelmintic activity against Haemonchus contortus nematode in sheep was determined a... 来源：ChEMBL 靶标：Ovis aries External Id：CHEMBL805850

实验名称：Anthelmintic activity against Haemonchus contortus nematode in sheep was determined a... 来源：ChEMBL 靶标：Ovis aries External Id：CHEMBL805849

实验名称：anthelmintic activity as the eggs per gram of faeces in sheep infected with 5000 Haem... 来源：ChEMBL 靶标：Bos taurus External Id：CHEMBL836624

实验名称：Partition coefficient in n-octanol/ water system at pH= 7.0 来源：ChEMBL 靶标：N/A External Id：CHEMBL634964

实验名称：anthelmintic activity as the percent reduction in faecal egg count in sheep infected ... 来源：ChEMBL 靶标：Bos taurus External Id：CHEMBL825601

实验名称：anthelmintic activity as the percent reduction in faecal egg count in sheep infected ... 来源：ChEMBL 靶标：Bos taurus External Id：CHEMBL825600

实验名称：anthelmintic activity as the eggs per gram of faeces in sheep infected with 5000 Haem... 来源：ChEMBL 靶标：Bos taurus External Id：CHEMBL836626

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PF 1022A英文别名

• PF 1022A