STAT6-IN-2

• 常用名: STAT6-IN-2
• 英文名: STAT6-IN-2
• CAS号: 1355594-85-2
• 分子量: 469.58
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₃₁N₅O₂
• 熔点: N/A
• 闪点: N/A

STAT6-IN-2用途

STAT6-IN-2(Comp R-84)是STAT6的抑制剂。STAT6-IN-2抑制引起嗜酸性粒细胞浸润的趋化因子eotaxin-3的分泌。STAT6-IN-2可用于免疫疾病研究[1]。

STAT6-IN-2名称

• 英文名: STAT6-IN-2

STAT6-IN-2生物活性

• 描述: STAT6-IN-2(Comp R-84)是STAT6的抑制剂。STAT6-IN-2抑制引起嗜酸性粒细胞浸润的趋化因子eotaxin-3的分泌。STAT6-IN-2可用于免疫疾病研究[1]。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> STAT
  信号通路 >> JAK/STAT信号通路 >> STAT
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Zhou L, et.al. STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells. Bioorg Med Chem. 2012 Jan 15;20(2):750-8.

STAT6-IN-2物理化学性质

• 分子式: C₂₈H₃₁N₅O₂
• 分子量: 469.58
• InChIKey: NQCIABFWMPKOJV-LJQANCHMSA-N
• SMILES: CC(C)C(C)NC(=O)c1cc(-c2cc3ccccc3n2C)cc(C(=O)NCCc2ccccn2)n1

STAT6-IN-2靶点实验

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实验名称：Inhibition of IL-4-induced human STAT6 tyrosine phosphorylation expressed in 293-EBNA... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 6 External Id：CHEMBL2214428

实验名称：Inhibition of mouse STAT6 expressed in BEAS2B cells assessed as inhibition of IL4-ind... 来源：ChEMBL 靶标：Signal transducer and transcription activator 6 External Id：CHEMBL2216406

实验名称：Inhibition of mouse STAT6 expressed in BEAS2B cells assessed as IL4/TNFalpha-induced ... 来源：ChEMBL 靶标：Signal transducer and transcription activator 6 External Id：CHEMBL2216404

实验名称：Inhibition of JAK2 up to 10 uM after 30 mins by colorimetric ELISA 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK2 External Id：CHEMBL2214427

实验名称：Inhibition of human STAT6 expressed in 293-EBNA cells assessed as inhibition of IL4-i... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 6 External Id：CHEMBL2213985

实验名称：Cytotoxicity against human 293-EBNA cells assessed as effect on luciferase activity a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2213986

实验名称：Cytotoxicity against human 293-EBNA cells assessed as effect on luciferase activity a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2213984

实验名称：Inhibition of mouse STAT6 expressed in BEAS2B cells assessed as IL3/TNFalpha-induced ... 来源：ChEMBL 靶标：Signal transducer and transcription activator 6 External Id：CHEMBL2216402

实验名称：Inhibition of human N-terminal HA/myc tagged STAT6 expressed in 293-EBNA cells assess... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 6 External Id：CHEMBL2213989

实验名称：Inhibition of mouse STAT6 expressed in BEAS2B cells assessed as IL4-induced eotaxin-3... 来源：ChEMBL 靶标：Signal transducer and transcription activator 6 External Id：CHEMBL2216403

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