4-[(3aS,4R,9bR)-6-ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid

• 常用名: 4-[(3aS,4R,9bR)-6-ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid
• 英文名: LIN28 inhibitor LI71
• CAS号: 1357248-83-9
• 分子量: 335.40
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₁NO₃
• 熔点: N/A
• 闪点: N/A

用途

LIN28 inhibitor LI71 是一种高效、细胞渗透性的 LIN28 抑制剂,能消除 LIN28 介导的寡核苷酸化,其 IC50 值为 7 uM。LIN28 inhibitor LI71 能直接绑定 CSD,抑制 LIN28 对 let-7 的作用活性。

名称

• 中文名: 4-[(3aS,4R,9bR)-6-ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid
• 英文名: LIN28 inhibitor LI71

生物活性

• 描述: LIN28 inhibitor LI71 是一种高效、细胞渗透性的 LIN28 抑制剂,能消除 LIN28 介导的寡核苷酸化,其 IC50 值为 7 uM。LIN28 inhibitor LI71 能直接绑定 CSD,抑制 LIN28 对 let-7 的作用活性。
• 相关类别:
  信号通路 >> 表观遗传学 >> 微RNA
  研究领域 >> 其他
• 靶点实验:

  IC50: 7 uM (LIN28)[1]

• 参考文献:

  [1]. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 Jun 5;23(10):3091-3101.

物理化学性质

• 分子式: C₂₁H₂₁NO₃
• 分子量: 335.40
• InChIKey: QWJMABCFVYELBB-GJYPPUQNSA-N
• SMILES: CCOc1cccc2c1NC(c1ccc(C(=O)O)cc1)C1CC=CC21
• 外观性状: 固体
• 储存条件: 2-8°C，密封，干燥

安全信息

• 危害码 (欧洲): Xi

靶点实验

查看更多实验

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