(E)-Necrosulfonamide

• 常用名: (E)-Necrosulfonamide
• 英文名: Necrosulfonamide
• CAS号: 1360614-48-7
• 分子量: 461.472
• 密度: 1.6±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₈H₁₅N₅O₆S₂
• 熔点: 257 °C(dec.)
• 闪点: N/A

(E)-Necrosulfonamide用途

Necrosulfonamide是一个MLKL药理抑制剂， 在HT-29细胞的 IC50是 124 nM.

(E)-Necrosulfonamide名称

• 中文名: (E)-Necrosulfonamide
• 英文名: Necrosulfonamide

(E)-Necrosulfonamide生物活性

• 描述: Necrosulfonamide是一种坏死性凋亡抑制剂,通过选择性靶向 ((MLKL)) 来阻断坏死体形成。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> 混合谱系激酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Steinhart L et al. Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells andovercome apoptosis resistance by inducing necroptosis. Cell Death Dis. 2013 Sep 12;

  [2]. Sun L et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012 Jan 20;148(1-2):213-27.

  [3]. Dunai ZA et al. Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells. PLoS One. 2012;7(7):

  [4]. Bae JH et al. Chemical regulation of signaling pathways to programmed necrosis. Arch Pharm Res. 2014 Jun;37(6):689-97.

(E)-Necrosulfonamide物理化学性质

• 密度: 1.6±0.1 g/cm3
• 熔点: 257 °C(dec.)
• 分子式: C₁₈H₁₅N₅O₆S₂
• 分子量: 461.472
• 精确质量: 461.046387
• LogP: 4.08
• 外观性状: 固体;Yellow to Brown to Dark green powder to crystal
• 折射率: 1.695
• 储存条件: 0-10°C;存放于惰性气体之中;避免光,空气,加热

(E)-Necrosulfonamide英文别名

• (E)-N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide
• (2E)-N-{4-[(3-Methoxy-2-pyrazinyl)sulfamoyl]phenyl}-3-(5-nitro-2-thienyl)acrylamide
• 2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-, (2E)-
• necrosulfonamide
• CHEBI:63770
• (2E)-N-{4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl}-3-(5-nitrothiophen-2-yl)prop-2-enamide